Open Access

Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway

  • Authors:
    • Junwei Shen
    • Yunchen Sun
    • Si Shen
    • Xu Luo
    • Jie Chen
    • Liang Zhu
  • View Affiliations

  • Published online on: April 19, 2019     https://doi.org/10.3892/mmr.2019.10177
  • Pages: 5105-5114
  • Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Portal hypertension is the primary cause of complications in patients with chronic liver diseases, and markedly impacts metabolism within the nervous system. Until recently, the role of portal hypertension in hepatocellular metabolism was unclear. The present study demonstrated that an increase in extracellular pressure significantly decreased hepatocellular glycogen concentrations in HepG2 and HL‑7702 cells. In addition, it reduced glycogen synthase activity, by inhibiting the phosphorylation of glycogen synthase 1. RNA‑seq analysis revealed that mechanical pressure suppressed glycogen synthesis by activating the p53/phosphatase and tensin homolog pathway, further suppressing glycogen synthase activity. The present study revealed an association between mechanical pressure and hepatocellular glycogen metabolism, and identified the regulatory mechanism of glycogen synthesis under pressure.
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June 2019
Volume 19 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
APA
Shen, J., Sun, Y., Shen, S., Luo, X., Chen, J., & Zhu, L. (2019). Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway. Molecular Medicine Reports, 19, 5105-5114. https://doi.org/10.3892/mmr.2019.10177
MLA
Shen, J., Sun, Y., Shen, S., Luo, X., Chen, J., Zhu, L."Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway". Molecular Medicine Reports 19.6 (2019): 5105-5114.
Chicago
Shen, J., Sun, Y., Shen, S., Luo, X., Chen, J., Zhu, L."Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway". Molecular Medicine Reports 19, no. 6 (2019): 5105-5114. https://doi.org/10.3892/mmr.2019.10177