Open Access

High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC

  • Authors:
    • Li Sun
    • Jing Sun
    • Jun‑Ding Song
  • View Affiliations

  • Published online on: April 10, 2019     https://doi.org/10.3892/mmr.2019.10146
  • Pages: 4881-4889
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of primary lung cancer (PLC) is increasing and is becoming a leading cause of cancer‑associated mortality worldwide. Non‑small cell lung cancer (NSCLC) accounts for ~80% of PLC cases and has the worst prognosis among malignant tumors. Deleted in liver cancer (DLC) proteins belong to the RhoGTPase‑activating protein family and are considered to be tumor suppressor genes. However, the role of the proteins, particularly DLC2 and DLC3, in NSCLC, has not been fully elucidated. The present study investigated the expression levels and prognostic values of DLCs in NSCLC using The Cancer Genome Atlas, the Genotype‑Tissue Expression project and Kaplan‑Meier plotter datasets. The current study demonstrated that the three DLCs were downregulated in NSCLC. High expression levels of DLC1 and DLC2 were associated with an improved survival in NSCLC. Additionally, the effects of DLCs on the proliferation and apoptosis of the lung cancer cell line A‑549 were investigated in vitro using a Cell Counting Kit‑8 assay and flow cytometry analysis. DLC2 and DLC3 overexpression inhibited proliferation and induced apoptosis in A549 cells. To the best of our knowledge, the current study was the first to investigate the expression level and prognostic values of DLC2 and DLC3 in NSCLC. The results indicated that DLC1 DLC2 and DLC3 serve specific roles in the occurrence and development of NSCLC, and may be considered as potential prognostic indicators in NSCLC.
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June 2019
Volume 19 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Sun, L., Sun, J., & Song, J. (2019). High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC. Molecular Medicine Reports, 19, 4881-4889. https://doi.org/10.3892/mmr.2019.10146
MLA
Sun, L., Sun, J., Song, J."High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC". Molecular Medicine Reports 19.6 (2019): 4881-4889.
Chicago
Sun, L., Sun, J., Song, J."High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC". Molecular Medicine Reports 19, no. 6 (2019): 4881-4889. https://doi.org/10.3892/mmr.2019.10146