Open Access

Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer

  • Authors:
    • Jian‑Feng Zhang
    • Wei Jiang
    • Qian‑Feng Zhang
    • Xiao‑Ling Kuai
    • Zhen‑Biao Mao
    • Zhi‑Wei Wang
  • View Affiliations

  • Published online on: April 4, 2019     https://doi.org/10.3892/mmr.2019.10128
  • Pages: 4613-4622
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is a leading cause of cancer‑associated mortality worldwide. Previous studies demonstrated that long noncoding RNAs (lncRNAs) may be dysregulated in GC and may serve important roles in cancer progression. The present study aimed to investigate the role of the novel lncRNA stomach cancer‑associated transcript 16 (STCAT16; Assembly Gene ID G038291) in the development and progression of GC. The present data suggested that the expression level of STCAT16 was decreased in GC tissues. The expression level of STCAT16 was identified to be associated with lymph node and tumour node metastasis stages. Furthermore, the expression level of STCAT16 was identified to be significantly associated with poor survival and prognosis. Knockdown of STCAT16 promoted proliferation, colony formation, migration and invasion of BGC‑823 cells. In contrast, these features were suppressed in AGS cells following overexpression of STCAT16. In vivo, tumour growth was significantly decreased following STCAT16 overexpression. Collectively, the present data suggested that the lncRNA STCAT16 may act as a tumour suppressor and may inhibit GC tumour cell growth and migration. Additionally, the decreased expression level of STCAT16 was identified to be associated with poor prognosis in patients with GC.

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June 2019
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Copy and paste a formatted citation
APA
Zhang, J., Jiang, W., Zhang, Q., Kuai, X., Mao, Z., & Wang, Z. (2019). Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer. Molecular Medicine Reports, 19, 4613-4622. https://doi.org/10.3892/mmr.2019.10128
MLA
Zhang, J., Jiang, W., Zhang, Q., Kuai, X., Mao, Z., Wang, Z."Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer". Molecular Medicine Reports 19.6 (2019): 4613-4622.
Chicago
Zhang, J., Jiang, W., Zhang, Q., Kuai, X., Mao, Z., Wang, Z."Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer". Molecular Medicine Reports 19, no. 6 (2019): 4613-4622. https://doi.org/10.3892/mmr.2019.10128