Role of neuroinflammation in neurodegenerative diseases (Review)

Chen,Wei‑Wei; Zhang,Xia; Huang,Wen‑Juan

doi:10.3892/mmr.2016.4948

Role of neuroinflammation in neurodegenerative diseases (Review)

Authors:
- Wei‑Wei Chen
- Xia Zhang
- Wen‑Juan Huang
View Affiliations

Affiliations: Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China
Published online on: February 29, 2016 https://doi.org/10.3892/mmr.2016.4948
Pages: 3391-3396
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Neurodegeneration is a phenomenon that occurs in the central nervous system through the hallmarks associating the loss of neuronal structure and function. Neurodegeneration is observed after viral insult and mostly in various so-called ‘neurodegenerative diseases’, generally observed in the elderly, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis that negatively affect mental and physical functioning. Causative agents of neurodegeneration have yet to be identified. However, recent data have identified the inflammatory process as being closely linked with multiple neurodegenerative pathways, which are associated with depression, a consequence of neurodegenerative disease. Accordingly, pro‑inflammatory cytokines are important in the pathophysiology of depression and dementia. These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro‑inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments. In this review, we investigated the role played by the inflammatory process in neurodegenerative diseases.

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