The impact of pulmonary metastasectomy from gastric cancer

  • Authors:
    • Yohei Oguri
    • Masayuki Okui
    • Takashi Yamamichi
    • Ayaka Asakawa
    • Masahiko Harada
    • Hirotoshi Horio
  • View Affiliations

  • Published online on: August 12, 2019     https://doi.org/10.3892/mco.2019.1910
  • Pages: 401-404
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Abstract

Gastric cancer remains the most commonly‑occurring cancer and the third most frequent cause of cancer‑associated mortality in Japan. Solitary pulmonary metastasis of gastric cancer is rare and the outcome of pulmonary metastasectomy is still unclear. Herein we report the impact of pulmonary resection in patients with metastasis from gastric cancer. The present study retrospectively reviewed the preoperative data and clinical courses of 10 patients who underwent pulmonary resection for metastasis from gastric cancer at our institution between July 1986 and December 2017. The data on the outcomes, including morbidity, mortality and survival, were obtained from the patient records. All patients were followed‑up from the time of pulmonary resection until mortality or referral to another hospital. The statistical analyses were performed using EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan), which is a graphical user interface for the R software program (The R Foundation for Statistical Computing, Vienna, Austria). The study population included 7 male patients and 3 female patients. A total of 5 patients underwent total gastrectomy, and 5 underwent distal gastrectomy. The median disease‑free interval after initial gastric resection was 34.5 months. Five patients received adjuvant chemotherapy, of the 10 thoracotomies, 5 were lobectomy, 3 were wedge resection and 2 were segmentectomy. The median overall survival following pulmonary metastasectomy was 59 months and the 5‑year survival rate was 40.5%. Taken together, the results of the present study suggest that pulmonary resection may be an effective therapeutic option for metastatic gastric cancer when a patient has a solitary metastatic lesion.

References

1 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Lin BR, Chang TC, Lee YC, Lee PH, Chang KJ and Liang JT: Pulmonary resection for colorectal cancer metastases: Duration between cancer onset and lung metastasis as an important prognostic factor. Ann Surg Oncol. 16:1026–1032. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Bölükbas S, Kudelin N, Eberlein M, Fisseler-Eckhoff A and Schirren J: The influence of the primary tumor on the long-term results of pulmonary metastasectomy for metastatic renal cell carcinoma. Thorac Cardiovasc Surg. 60:390–397. 2012.PubMed/NCBI

4 

Koga S, Takebayashi M, Kaibara N, Nishidoi H, Kimura O, Kawasumi H and Makino M: Pathological characteristics of gastric cancer that develop hematogenous recurrence, with special reference to the site of recurrence. J Surg Oncol. 36:239–242. 1987. View Article : Google Scholar : PubMed/NCBI

5 

Kong JH, Lee J, Yi CA, Park SH, Park JO, Park YS, Lim HY, Park KW and Kang WK: Lung metastases in metastatic gastric cancer: Pattern of lung metastases and clinical outcome. Gastric Cancer. 15:292–298. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Thomford NR, Woolner LB and Clagett OT: The surgical treatment of metastatic tumor in the lung. J Thoracic Cardiovasc Surg. 49:357–363. 1965.

7 

Sano T and Aiko T: New Japanese classifications and treatment guidelines for gastric cancer: Revision concepts and major revised points. Gastric Cancer. 14:97–100. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Kanda Y: Investigation of the freely-available easy-to-use software EZR for medical statistics. Bone Marrow Transplant. 48:452–458. 2013. View Article : Google Scholar : PubMed/NCBI

9 

NCCN clinical practice guidelines in Oncology, Colon Cancer. simplehttp://www.nccn.org/professionals/physician_gls/pdf/colon.pdf13–March. 2017

10 

Nakayama H1, Ichinose S, Kato Y, Ito H, Masui K and Kameda Y: Long-term survival after a surgical resection of pulmonary metastases from gastric cancer: report of a case. Surg Today. 38:150–153. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Dupont JB Jr, Lee JR, Burton GR and Cohn I Jr: Adenocarcinoma of the stomach: Review of 1,497 cases. Cancer. 41:941–947. 1978. View Article : Google Scholar : PubMed/NCBI

12 

Ishii T, Ikegami N, Hosoda Y, Koide O and Kaneko M: The biological behavior of gastric cancer. J Pathol. 134:97–115. 1981. View Article : Google Scholar : PubMed/NCBI

13 

Kanemitsu Y, Kondo H, Katai H, Nakayama H, Asamura H, Tsuchiya R and Naruke T: Surgical resection of pulmonary metastases from gastric cancer. J Surg Oncol. 69:147–150. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Ohkuwa M, Ohtsu A, Boku N, Yoshida S, Miyata Y, Shirao K, Shimada Y and Kurihara M: Long-term results for patients with unresectable gastric cancer who received chemotherapy in the Japan Clinical Oncology Group (JCOG) trials. Gastric Cancer. 3:145–150. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Yoshida M, Ohtsu A, Boku N, Miyata Y, Shirao K, Shimada Y, Hyodo I, Koizumi W, Kurihara M, Yoshida S and Yamamoto S: Long-term survival and prognostic factors in patients with metastatic gastric cancers treated with chemotherapy in the Japan Clinical Oncology Group (JCOG) study. Jpn J Clin Oncol. 34:654–659. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Nakayama H, Ichinose S, Kato Y, Ito H, Masui K and Kameda Y: Long-term survival after a surgical resection of pulmonary metastases from gastric cancer: Report of a case. Surg Today. 38:150–153. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Ogura M, Tanaka N, Furuya T, Nomura Y, Nagai M, Takahashi M, Takayama T, Hirao H, Nakamura H and Suzuki Y: A case of long-term survival after undergoing S-1 treatment and splenectomy for liver, lung and splenic metastases following curative distal gastrectomy for gastric cancer. Gan To Kagaku Ryoho. 37:1125–1129. 2010.(In Japanese). PubMed/NCBI

18 

Kobayashi Y, Fukui T, Ito S, Shitara K, Ito S, Hatooka S and Mitsudomi T: Pulmonary metastasectomy for gastric cancer: A 13-year single-institution experience. Surg Today. 43:1382–1389. 2013. View Article : Google Scholar : PubMed/NCBI

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October 2019
Volume 11 Issue 4

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Copy and paste a formatted citation
APA
Oguri, Y., Okui, M., Yamamichi, T., Asakawa, A., Harada, M., & Horio, H. (2019). The impact of pulmonary metastasectomy from gastric cancer. Molecular and Clinical Oncology, 11, 401-404. https://doi.org/10.3892/mco.2019.1910
MLA
Oguri, Y., Okui, M., Yamamichi, T., Asakawa, A., Harada, M., Horio, H."The impact of pulmonary metastasectomy from gastric cancer". Molecular and Clinical Oncology 11.4 (2019): 401-404.
Chicago
Oguri, Y., Okui, M., Yamamichi, T., Asakawa, A., Harada, M., Horio, H."The impact of pulmonary metastasectomy from gastric cancer". Molecular and Clinical Oncology 11, no. 4 (2019): 401-404. https://doi.org/10.3892/mco.2019.1910