Open Access

Treatments and outcomes of older patients with esophageal cancer: Comparison with younger patients

  • Authors:
    • Yoshifumi Matsumoto
    • Kazuyoshi Kimura
    • Qiliang Zhou
    • Kenta Sasaki
    • Takuro Saiki
    • Masato Moriyama
    • Yasuo Saijo
  • View Affiliations

  • Published online on: August 9, 2019     https://doi.org/10.3892/mco.2019.1909
  • Pages: 383-389
  • Copyright: © Matsumoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The number of older patients with esophageal cancer (EC) is increasing due to the population aging and increasing life expectancy. However, no optimal treatment strategy for older patients with EC has been established to date. The aim of the present study was to review and compare the treatment modalities and outcomes of 990 younger and older patients diagnosed with EC in our institution. The patients were divided into younger (≤74 years) and older (≥75 years) groups. The majority of the patients in both groups had early‑stage EC and were treated by endoscopic submucosal dissection (ESD). The older patients with locally advanced (stage II and III) EC were more likely to undergo chemoradiotherapy rather than esophagectomy. Among the older patients, 22% selected best supportive care. The disease‑specific survival rate of the older patients was significantly lower compared with that of the younger patients, which was likely due to the less intense treatment modalities applied. The prognosis following esophagectomy was significantly better compared with that of chemoradiotherapy in the younger, but not in the older patients. In conclusion, the poorer prognosis of older patients (aged ≥75 years) with stage I EC may improve with multidisciplinary treatment after ESD. Although CRT is currently considered the optimal treatment for older patients with stage II/III EC, more efficient treatment modalities are urgently required.

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October 2019
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Copy and paste a formatted citation
APA
Matsumoto, Y., Kimura, K., Zhou, Q., Sasaki, K., Saiki, T., Moriyama, M., & Saijo, Y. (2019). Treatments and outcomes of older patients with esophageal cancer: Comparison with younger patients. Molecular and Clinical Oncology, 11, 383-389. https://doi.org/10.3892/mco.2019.1909
MLA
Matsumoto, Y., Kimura, K., Zhou, Q., Sasaki, K., Saiki, T., Moriyama, M., Saijo, Y."Treatments and outcomes of older patients with esophageal cancer: Comparison with younger patients". Molecular and Clinical Oncology 11.4 (2019): 383-389.
Chicago
Matsumoto, Y., Kimura, K., Zhou, Q., Sasaki, K., Saiki, T., Moriyama, M., Saijo, Y."Treatments and outcomes of older patients with esophageal cancer: Comparison with younger patients". Molecular and Clinical Oncology 11, no. 4 (2019): 383-389. https://doi.org/10.3892/mco.2019.1909