Open Access

Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report

  • Authors:
    • Takayuki Akasaki
    • Takahiro Einama
    • Keita Tashiro
    • Hiromi Nagata
    • Kenji Yamazaki
    • Makoto Nishikawa
    • Mayumi Hoshikawa
    • Akifumi Kimura
    • Takuji Noro
    • Sho Ogata
    • Suefumi Aosasa
    • Yoshiki Kajiwara
    • Eiji Shinto
    • Yoshihisa Yaguchi
    • Shuichi Hiraki
    • Hironori Tsujimoto
    • Kazuo Hase
    • Hideki Ueno
    • Junji Yamamoto
  • View Affiliations

  • Published online on: July 22, 2019     https://doi.org/10.3892/mco.2019.1902
  • Pages: 359-363
  • Copyright: © Akasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Granulocyte colony‑stimulating factor (G‑CSF) is a naturally occurring glycoprotein that stimulates the proliferation of precursor cells in the bone marrow and their maturation into fully differentiated neutrophils. G‑CSF‑producing cancers rarely occur in the digestive system, particularly the pancreas. Herein we report the rare case of a G‑CSF‑producing pancreatic carcinoma associated with severe anemia due to bleeding in the duodenum, which was successfully treated with surgery. A 79 year‑old man presented with epigastralgia and anemia at our institution. Esophagogastroduodenoscopy revealed a duodenal tumor, which was diagnosed as a poorly differentiated adenocarcinoma. To control breeding, subtotal stomach‑preserving pancreaticoduodenectomy was performed. The excised tumor measured 86x55x54 mm. It was primarily located in the pancreas and compressed the pancreatic parenchyma and main bile duct. It comprised poorly differentiated adenocarcinoma, and prominent neutrophil infiltration was noted around the tumor. Immunohistochemical examination revelaed that the tumor was positive for G‑CSF expression. Based on these results, a final diagnosis of G‑CSF‑producing primary pancreatic cancer was made. At 18 months following surgery, the patient was alive without recurrence.

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October 2019
Volume 11 Issue 4

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Copy and paste a formatted citation
APA
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M. ... Yamamoto, J. (2019). Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report. Molecular and Clinical Oncology, 11, 359-363. https://doi.org/10.3892/mco.2019.1902
MLA
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M., Hoshikawa, M., Kimura, A., Noro, T., Ogata, S., Aosasa, S., Kajiwara, Y., Shinto, E., Yaguchi, Y., Hiraki, S., Tsujimoto, H., Hase, K., Ueno, H., Yamamoto, J."Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 11.4 (2019): 359-363.
Chicago
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M., Hoshikawa, M., Kimura, A., Noro, T., Ogata, S., Aosasa, S., Kajiwara, Y., Shinto, E., Yaguchi, Y., Hiraki, S., Tsujimoto, H., Hase, K., Ueno, H., Yamamoto, J."Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 11, no. 4 (2019): 359-363. https://doi.org/10.3892/mco.2019.1902