Open Access

Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis

  • Authors:
    • Mitsuyoshi Okazaki
    • Katsunobu Oyama
    • Jun Kinoshita
    • Tomoharu Miyashita
    • Hidehiro Tajima
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Sachio Fushida
    • Tetsuo Ohta
  • View Affiliations

  • Published online on: July 15, 2019     https://doi.org/10.3892/mco.2019.1897
  • Pages: 343-348
  • Copyright: © Okazaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Totally implantable vascular access devices (TIVADs) are often used to administer chemotherapy by prolonged intravenous infusion. The objective of the present study was to investigate the incidence of long‑term complications and identify risk factors associated with TIVAD placement in patients with gastric cancer. A total of 121 patients with gastric cancer who had undergone 150 TIVAD placement procedures for chemotherapy or supportive care were enrolled in the present retrospective cohort study. A number of risk factors were analyzed, including age, sex, hypertension, diabetes mellitus, history of thrombosis, body mass index, disease stage, and site and purpose of TIVAD. In total, 40 TIVADs (26.7%) developed long‑term complications, of which 27 (18.0%) were infections, seven (4.7%) were catheter‑related deep vein thrombosis (CR‑DVT), and six (4.0%) were obstructions. Chemotherapy was associated with an increased rate of infectious adverse events (odds ratio 2.925; 95% CI, 1.104‑7.750; P=0.031) according to the multivariate analysis. CR‑DVT occurred more frequently in upper arm ports than in chest wall ports; however, this difference was not statistically significant (7.5 vs. 0.0%; P=0.084) according to the univariable analysis. All CR‑DVTs developed in the upper arm sites. Chemotherapy and the upper arm site were associated with long‑term complications in patients with TIVAD. However, further studies are needed to confirm the findings of the present study and to determine the reasons for the high incidence of long‑term complications in these patients.

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October 2019
Volume 11 Issue 4

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APA
Okazaki, M., Oyama, K., Kinoshita, J., Miyashita, T., Tajima, H., Takamura, H. ... Ohta, T. (2019). Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis. Molecular and Clinical Oncology, 11, 343-348. https://doi.org/10.3892/mco.2019.1897
MLA
Okazaki, M., Oyama, K., Kinoshita, J., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis". Molecular and Clinical Oncology 11.4 (2019): 343-348.
Chicago
Okazaki, M., Oyama, K., Kinoshita, J., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis". Molecular and Clinical Oncology 11, no. 4 (2019): 343-348. https://doi.org/10.3892/mco.2019.1897