Imaging features that distinguish pure ductal carcinoma in situ (DCIS) from DCIS with microinvasion

  • Authors:
    • Hongli Wang
    • Jinjiang Lin
    • Jianguo Lai
    • Cui Tan
    • Yaping Yang
    • Ran Gu
    • Xiaofang Jiang
    • Fengtao Liu
    • Yue Hu
    • Fengxi Su
  • View Affiliations

  • Published online on: July 3, 2019     https://doi.org/10.3892/mco.2019.1891
  • Pages: 313-319
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Abstract

Patients with ductal carcinoma in situ with microinvasion (DCISM) have worse cancer‑specific survival, disease‑free survival and overall survival, and a higher mortality rate compared with patients with ductal carcinoma in situ (DCIS). Distinguishing DCISM from DCIS via preoperative imaging could help to predict the prognosis of patients. The present study compared the sonographic and mammographic features of patients with DCIS and DCISM. A total of 147 women (94 patients with DCIS and 53 patients with DCISM) were retrospectively included. The sonographic lesions were classified as either masses or non‑mass abnormalities. The lesions observed on mammography were classified as calcifications only, mass, asymmetry or architectural distortion. Statistical comparisons were performed using the Mann‑Whitney U test, χ2 test, Fisher's exact test and multiple logistic regression analysis. Univariate and multivariate analyses showed that the presence of calcifications (P=0.038) and vascularity (P=0.025) on sonography were associated with DCISM. Furthermore, a lager distribution of calcifications was associated with a higher likelihood of DCISM (P=0.002). In conclusion, the presence of calcifications and vascularity on sonography or a lager distribution of calcifications on mammography may suggest DCISM.

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September 2019
Volume 11 Issue 3

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Copy and paste a formatted citation
APA
Wang, H., Lin, J., Lai, J., Tan, C., Yang, Y., Gu, R. ... Su, F. (2019). Imaging features that distinguish pure ductal carcinoma in situ (DCIS) from DCIS with microinvasion. Molecular and Clinical Oncology, 11, 313-319. https://doi.org/10.3892/mco.2019.1891
MLA
Wang, H., Lin, J., Lai, J., Tan, C., Yang, Y., Gu, R., Jiang, X., Liu, F., Hu, Y., Su, F."Imaging features that distinguish pure ductal carcinoma in situ (DCIS) from DCIS with microinvasion". Molecular and Clinical Oncology 11.3 (2019): 313-319.
Chicago
Wang, H., Lin, J., Lai, J., Tan, C., Yang, Y., Gu, R., Jiang, X., Liu, F., Hu, Y., Su, F."Imaging features that distinguish pure ductal carcinoma in situ (DCIS) from DCIS with microinvasion". Molecular and Clinical Oncology 11, no. 3 (2019): 313-319. https://doi.org/10.3892/mco.2019.1891