Prognostic significance of the postoperative level and recovery rate of serum albumin in patients with curatively resected pancreatic ductal adenocarcinoma

  • Authors:
    • Yutaka Nakano
    • Minoru Kitago
    • Masahiro Shinoda
    • Hiroshi Yagi
    • Yuta Abe
    • Kiminori Takano
    • Go Oshima
    • Ayano Takeuch
    • Yutaka Endo
    • Yuko Kitagawa
  • View Affiliations

  • Published online on: June 19, 2019     https://doi.org/10.3892/mco.2019.1883
  • Pages: 270-278
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Abstract

The aim of the present study was to investigate the clinicopathological features and prognostic factors associated with pre‑ and postoperative serum albumin levels in patients with curatively resected pancreatic ductal adenocarcinoma (PDAC). To achieve this, the data of patients who underwent pancreatectomy for PDAC between January 1995 and March 2016 were retrospectively reviewed, and the pre‑ and postoperative serum albumin levels at postoperative months (POMs) 3, 6, and 12 were evaluated. The serum albumin recovery rate was also investigated. A total of 196 patients were enrolled in the present study. In the multivariate Cox regression analysis, lymph node metastasis [hazard ratio (HR): 1.65; P=0.022], serum albumin level at POM 12 (≥3.9 g/dl; HR: 0.60; P=0.017), and serum albumin recovery rate at POM 12 (≥1.00; HR: 0.60; P=0.017) were independent prognostic factors for disease‑free survival. Lymph node metastasis (HR: 1.79; P=0.013) and serum albumin level at POM 12 (≥3.9 g/dl) (HR: 0.60; P=0.033) were independent prognostic factors for overall survival. These results indicated that the postoperative level and recovery rate of serum albumin are potential biomarkers for predicting the prognosis of patients with curatively resected PDAC. However, further studies are required in order to investigate the survival benefit of increasing postoperative serum albumin levels in these patients.
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September 2019
Volume 11 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Nakano, Y., Kitago, M., Shinoda, M., Yagi, H., Abe, Y., Takano, K. ... Kitagawa, Y. (2019). Prognostic significance of the postoperative level and recovery rate of serum albumin in patients with curatively resected pancreatic ductal adenocarcinoma. Molecular and Clinical Oncology, 11, 270-278. https://doi.org/10.3892/mco.2019.1883
MLA
Nakano, Y., Kitago, M., Shinoda, M., Yagi, H., Abe, Y., Takano, K., Oshima, G., Takeuch, A., Endo, Y., Kitagawa, Y."Prognostic significance of the postoperative level and recovery rate of serum albumin in patients with curatively resected pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 11.3 (2019): 270-278.
Chicago
Nakano, Y., Kitago, M., Shinoda, M., Yagi, H., Abe, Y., Takano, K., Oshima, G., Takeuch, A., Endo, Y., Kitagawa, Y."Prognostic significance of the postoperative level and recovery rate of serum albumin in patients with curatively resected pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 11, no. 3 (2019): 270-278. https://doi.org/10.3892/mco.2019.1883