Open Access

Anthracycline‑induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment (Review)

  • Authors:
    • Fengfeng Cai
    • Manuel Antonio Falar Luis
    • Xiaoyan Lin
    • Minghong Wang
    • Lu Cai
    • Chunmei Cen
    • Ewelina Biskup
  • View Affiliations

  • Published online on: May 8, 2019     https://doi.org/10.3892/mco.2019.1854
  • Pages: 15-23
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well‑recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data support oxidative stress as the etiology of anthracycline‑induced cardiotoxicity. The objective of this paper was to provide a review of the clinical classification, risk factors, monitoring and prevention of anthracycline‑induced cardiotoxicity in patients with breast cancer.

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Copy and paste a formatted citation
APA
Cai, F., Luis, M.A., Lin, X., Wang, M., Cai, L., Cen, C., & Biskup, E. (2019). Anthracycline‑induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment (Review). Molecular and Clinical Oncology, 11, 15-23. https://doi.org/10.3892/mco.2019.1854
MLA
Cai, F., Luis, M. A., Lin, X., Wang, M., Cai, L., Cen, C., Biskup, E."Anthracycline‑induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment (Review)". Molecular and Clinical Oncology 11.1 (2019): 15-23.
Chicago
Cai, F., Luis, M. A., Lin, X., Wang, M., Cai, L., Cen, C., Biskup, E."Anthracycline‑induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment (Review)". Molecular and Clinical Oncology 11, no. 1 (2019): 15-23. https://doi.org/10.3892/mco.2019.1854