Open Access

Long non‑coding RNAs in lung cancer: Regulation patterns, biologic function and diagnosis implications (Review)

  • Authors:
    • Lin Jiang
    • Zheng Li
    • Ranran Wang
  • View Affiliations

  • Published online on: July 29, 2019     https://doi.org/10.3892/ijo.2019.4850
  • Pages: 585-596
  • Copyright : © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Lung cancer is the most common malignancy with the highest mortality worldwide. Emerging research has demonstrated that long non‑coding RNAs (lncRNAs), a key genomic product, are commonly dysregulated in lung cancer and have significant functions in lung cancer initiation, progression and therapeutic response. lncRNAs may interact with DNA, RNA or proteins, as tumor suppressor genes or oncogenes, to regulate gene expression and cell signaling pathways. In the present review, first a summary was presented of the causal effects of dysregulated lncRNAs in lung cancer. Next, the function and specific mechanisms of lncRNA‑mediated tumorigenesis, metastasis and drug resistance in lung cancer were discussed. Finally, the potential roles of lncRNAs as biomarkers for lung cancer were explored.
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September 2019
Volume 55 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Jiang, L., Li, Z., & Wang, R. (2019). Long non‑coding RNAs in lung cancer: Regulation patterns, biologic function and diagnosis implications (Review). International Journal of Oncology, 55, 585-596. https://doi.org/10.3892/ijo.2019.4850
MLA
Jiang, L., Li, Z., Wang, R."Long non‑coding RNAs in lung cancer: Regulation patterns, biologic function and diagnosis implications (Review)". International Journal of Oncology 55.3 (2019): 585-596.
Chicago
Jiang, L., Li, Z., Wang, R."Long non‑coding RNAs in lung cancer: Regulation patterns, biologic function and diagnosis implications (Review)". International Journal of Oncology 55, no. 3 (2019): 585-596. https://doi.org/10.3892/ijo.2019.4850