Inflammatory responses induced by Helicobacter pylori on the carcinogenesis of gastric epithelial GES‑1 cells

  • Authors:
    • Jianjun Wang
    • Yongliang Yao
    • Qinghui Zhang
    • Shasha Li
    • Lijun Tang
  • View Affiliations

  • Published online on: April 9, 2019     https://doi.org/10.3892/ijo.2019.4775
  • Pages: 2200-2210
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Abstract

Helicobacter pylori (HP) is a pathogenic bacterium associated with chronic gastritis, gastric ulcer and gastric cancer. In the present study, the primary carcinogenesis process of normal gastric epithelial cells (GES‑1) infected with HP was investigated. It was determined that infected gastric mucosal epithelial GES‑1 cells secreted increased interleukin‑8 (IL‑8) and IL‑23, and exhibited enhanced expression of inducible nitric oxide synthase and cyclooxygenase‑2, inducing inflammatory reactions and resulting in apoptosis. The bacterial infection significantly increased the expression of carcinogenesis‑associated genes, including p16, c‑Myc, p53 and p21, as well as the expression of cell surface signaling molecules cluster of differentiation 44 (CD44) and CD54 in GES‑1 cells or tissues of patients with gastritis and gastric cancer in vitro or in vivo. Simultaneously, the migration and invasion abilities of normal gastric epithelial GES‑1 cells were increased following HP infection. These observations demonstrated that the inflammatory response of HP infection could cause normal gastric epithelial cells to undergo significant cancerous reactions, indicating that HP is a risk factor for gastric cancer.
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June 2019
Volume 54 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Wang, J., Yao, Y., Zhang, Q., Li, S., & Tang, L. (2019). Inflammatory responses induced by Helicobacter pylori on the carcinogenesis of gastric epithelial GES‑1 cells. International Journal of Oncology, 54, 2200-2210. https://doi.org/10.3892/ijo.2019.4775
MLA
Wang, J., Yao, Y., Zhang, Q., Li, S., Tang, L."Inflammatory responses induced by Helicobacter pylori on the carcinogenesis of gastric epithelial GES‑1 cells". International Journal of Oncology 54.6 (2019): 2200-2210.
Chicago
Wang, J., Yao, Y., Zhang, Q., Li, S., Tang, L."Inflammatory responses induced by Helicobacter pylori on the carcinogenesis of gastric epithelial GES‑1 cells". International Journal of Oncology 54, no. 6 (2019): 2200-2210. https://doi.org/10.3892/ijo.2019.4775