Journal Articles

Nanoparticle strategies for cancer therapeutics: Nucleic acids, polyamines, bovine serum amine oxidase and iron oxide nanoparticles (Review)

Enzo Agostinelli, Fabio Vianello, Giuseppe Magliulo, Thresia Thomas, T. J. Thomas

Pages: 5-16 Published online on: 14 October 2014

The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications (Review)

Yukie Sato-Kuwabara, Sonia A. Melo, Fernando A. Soares, George A. Calin

Pages: 17-27 Published online on: 17 October 2014
Open Access

Programmed death-1 blockade enhances the antitumor effects of peptide vaccine-induced peptide-specific cytotoxic T lymphocytes

Yu Sawada, Toshiaki Yoshikawa, Manami Shimomura, Tatsuaki Iwama, Itaru Endo, Tetsuya Nakatsura

Pages: 28-36 Published online on: 30 October 2014
Open Access

Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5‑fluorouracil on the HT‑29 colon cancer cell line

Alexander Hedbrant, Ann Erlandsson, Dick Delbro, Jonny Wijkander

Pages: 37-46 Published online on: 07 October 2014
Open Access

Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells

Masaki Mori, Toshiaki Hitora, Osamu Nakamura, Yoshiki Yamagami, Ryosuke Horie, Hideki Nishimura, Tetsuji Yamamoto

Pages: 47-54 Published online on: 23 October 2014

Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens

Teppei Yamada, Yasuhiro Terazaki, Shinjiro Sakamoto, Koichi Yoshiyama, Satoko Matsueda, Nobukazu Komatsu, Kayoko Waki, Akira Yamada, Akihiko Kawahara, Masayoshi Kage, Shunichi Sugawara, Yuichi Yamashita, Tetsuro Sasada, Shinzo Takamori, Kyogo Itoh

Pages: 55-62 Published online on: 07 October 2014

5-FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53-mutated colon cancer cells

Tomofumi Akasaka, Masahiko Tsujii, Jumpei Kondo, Yoshito Hayashi, Jin  Ying, Yuquan  Lu, Motohiko Kato, Takuya Yamada, Shunsuke  Yamamoto, Takuya Inoue, Yoshiki Tsujii, Akira Maekawa, Tetsuji Fujinaga, Eri  Shiraishi, Satoshi Hiyama, Takahiro Inoue, Shinichiro Shinzaki, Kenji  Watabe, Tsutomu  Nishida, Hideki Iijima, Tetsuo Takehara

Pages: 63-70 Published online on: 06 October 2014

Strong T‑cell costimulation can reactivate tumor antigen‑specific T cells in late‑stage metastasized colorectal carcinoma patients: Results from a phase Ⅰ clinical study

Volker Schirrmacher, Christoph Schlude, Jürgen Weitz, Philipp Beckhove

Pages: 71-77 Published online on: 06 October 2014

Pancreatic cancer immunotherapy using a tumor lysate vaccine, engineered to express α-gal epitopes, targets pancreatic cancer stem cells

Tsukasa Tanida, Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Kenta Furukawa, Yuji Nonaka, Hirofumi Akita, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Shogo Kobayashi, Hidetoshi Eguchi, Masaki Mori, Yuichiro Doki

Pages: 78-90 Published online on: 21 October 2014

Transformation of NIH3T3 mouse fibroblast cells by MUC16 mucin (CA125) is driven by its cytoplasmic tail

Panagiota Giannakouros, Isabelle Matte, Claudine Rancourt, Alain Piché

Pages: 91-98 Published online on: 14 October 2014

Autoacetylation regulates differentially the roles of ARD1 variants in tumorigenesis

Ji Hae Seo, Ji-Hyeon Park, Eun Ji Lee, Tam Thuy Lu Vo, Hoon Choi, Jae Kyung Jang, Hee-Jun Wee, Bum Ju Ahn, Jong-Ho Cha, Min Wook Shin, Kyu-Won Kim

Pages: 99-106 Published online on: 17 October 2014

Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues

Andrej Nikoshkov, Kristina Broliden, Sanaz Attarha, Vitali Sviatoha, Ann‑Cathrin Hellström, Miriam Mints, Sonia Andersson

Pages: 107-112 Published online on: 23 October 2014

Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma

Sze-Kwan Lam, Yuan-Yuan Li, Chun-Yan Zheng, James Chung-Man Ho

Pages: 113-122 Published online on: 21 October 2014

Prognostic significance of SOX18 expression in non-small cell lung cancer

Aleksandra Jethon, Bartosz Pula, Mateusz Olbromski, Bozena Werynska, Beata Muszczynska-Bernhard, Wojciech Witkiewicz, Piotr Dziegiel, Marzena Podhorska-Okolow

Pages: 123-132 Published online on: 07 October 2014

+TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules

Geethu Emily Thomas, Jamuna S. Sreeja, K. K. Gireesh, Hindol Gupta, Tapas K. Manna

Pages: 133-146 Published online on: 07 October 2014

Potent tumor tropism of induced pluripotent stem cells and induced pluripotent stem cell-derived neural stem cells in the mouse intracerebral glioma model

Tomohiro Yamazoe, Shinichiro Koizumi, Tomohiro Yamasaki, Shinji Amano, Tsutomu Tokuyama, Hiroki Namba

Pages: 147-152 Published online on: 08 October 2014

Mutation of β-catenin in a radiation and estrogen breast cancer model

Debasish Roy, Gloria M. Calaf

Pages: 153-160 Published online on: 22 October 2014

MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma

Xiyan Xiao, Liang Zhou, Pengyu Cao, Hongli Gong, Yanping Zhang

Pages: 161-174 Published online on: 10 October 2014

Prognostic significance and therapeutic implications of peroxisome proliferator-activated receptor γ overexpression in human pancreatic carcinoma

Yan Zhang, Hui-Yan Luo, Guang-Lin Liu, De-Shen Wang, Zhi-Qiang Wang, Zhao-Lei Zeng, Rui-Hua Xu

Pages: 175-184 Published online on: 17 October 2014

Silencing of galectin-3 represses osteosarcoma cell migration and invasion through inhibition of FAK/Src/Lyn activation and β-catenin expression and increases susceptibility to chemotherapeutic agents

Ga Bin Park, Dae-Jin Kim, Yeong-Seok Kim, Hyun-Kyung Lee, Chang Wan Kim, Dae Young Hur

Pages: 185-194 Published online on: 22 October 2014

The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance

Xinjiang Zhu, Jian Liu, Xiaoyang Xu, Chundong Zhang, Dongqiu Dai

Pages: 195-204 Published online on: 30 October 2014

Eps8 regulates cellular proliferation and migration of breast cancer

Cheng Chen, Zhongheng Liang, Wenhuan Huang, Xinxin Li, Fangliang Zhou, Xiang Hu, Mei Han, Xiaofeng Ding, Shuanglin Xiang

Pages: 205-214 Published online on: 17 October 2014

HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation

Xuhong Zhu, Qin Li, Shuang Li, Bote Chen, Haidong Zou

Pages: 215-222 Published online on: 21 October 2014

HIF2α is associated with poor prognosis and affects the expression levels of survivin and cyclin D1 in gastric carcinoma

Wei-Wei Tong, Guang-Hui Tong, Xie-Xiao Chen, Hua-Chuan Zheng, Yin-Zhao Wang

Pages: 233-242 Published online on: 22 October 2014

Oxime bond-linked daunorubicin-GnRH-III bioconjugates exert antitumor activity in castration-resistant prostate cancer cells via the type I GnRH receptor

Marina Montagnani Marelli, Marilena Manea, Roberta M. Moretti, Monica Marzagalli, Patrizia Limonta

Pages: 243-253 Published online on: 24 October 2014

TIPE2 inhibits TNF-α-induced hepatocellular carcinoma cell metastasis via Erk1/2 downregulation and NF-κB activation

Yue Hua Zhang, Hong Qiong Yan, Fang Wang, Yan Yan Wang, Yi Na Jiang, Yi Nan Wang, Feng Guang Gao

Pages: 254-264 Published online on: 23 October 2014

Esculetin (6,7-dihydroxycoumarin): A potential cancer chemopreventive agent through suppression of Sp1 in oral squamous cancer cells

Jin Hyoung Cho, Jae-Cheon Shin, Jung-Jae Cho, Yung Hyun Choi, Jung-Hyun Shim, Jung-Il Chae

Pages: 265-271 Published online on: 07 October 2014

Alteration of epithelial-mesenchymal transition markers in human normal ovaries and neoplastic ovarian cancers

Bo-Rim Yi, Tae-Hee Kim, Ye-Seul Kim, Kyung-Chul Choi

Pages: 272-280 Published online on: 07 October 2014

Real-time quantitative RT-PCR detection of circulating tumor cells from breast cancer patients

Maowen Guo, Xiaotian Li, Shaohua Zhang, Hua Song, Wenhui Zhang, Xueyi Shang, Yuling Zheng, Hua Jiang, Qingyu Lv, Yongqiang Jiang, Huaijie Hao

Pages: 281-289 Published online on: 29 October 2014

Upregulation of CRMP4, a new prostate cancer metastasis suppressor gene, inhibits tumor growth in a nude mouse intratibial injection model

Wei Zhou, Peigen Xie, Mao Pang, Bu Yang, Youqiang Fang, Tao Shu, Chang Liu, Xuan Wang, Liangming Zhang, Shangfu Li, Limin Rong

Pages: 290-298 Published online on: 10 October 2014

Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells

Yuting Liu, Xiao Wang, Ying Wang, Yi Zhang, Kai Zheng, Haizhao Yan, Li Zhang, Wenbo Chen, Xiaoyan Wang, Qiuying Liu, Shaoxiang Wang, Yifei Wang

Pages: 299-307 Published online on: 20 October 2014

Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment

Zoya Cohen, Yair Maimon, Merav Yoeli-Lerner, Peiying Yang, Noah Samuels, Raanan Berger

Pages: 308-316 Published online on: 17 October 2014

SOX2 promotes tumorigenicity and inhibits the differentiation of I-type neuroblastoma cells

Shaobo Yang, Jicui Zheng, Xianmin Xiao, Ting Xu, Weitao Tang, Haitao Zhu, Lin Yang, Shan Zheng, Kuiran Dong, Guomin Zhou, Yang Wang

Pages: 317-323 Published online on: 17 October 2014

The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells

Stefan Brenner, Juliane Riha, Benedikt Giessrigl, Theresia Thalhammer, Michael Grusch, Georg Krupitza, Bruno Stieger, Walter Jäger

Pages: 324-332 Published online on: 24 October 2014

Decreased expression of the SPOP gene is associated with poor prognosis in glioma

Dacheng Ding, Tao Song, Wu Jun, Zeming Tan, Jiasheng Fang

Pages: 333-341 Published online on: 24 October 2014

A novel pyrido-thieno-pyrimidine derivative activates p53 through induction of phosphorylation and acetylation in colorectal cancer cells

Mi Ae Kang, Mi-Sook Kim, Ji Young Kim, Young-Joo Shin, Jie-Young Song, Jae-Hoon Jeong

Pages: 342-350 Published online on: 22 October 2014

The key role of PML in IFN-α induced cellular senescence of human mesenchymal stromal cells

Shan Fu, Jieping Wei, Gang Wang, Binsheng Wang, Yebo Wang, Xiaoyu Lai, He Huang

Pages: 351-359 Published online on: 30 October 2014

Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo

Wenkai Xiao, Yajie Jiang, Qiuxu Men, Ling Yuan, Zebo Huang, Ting Liu, Wenhua Li, Xin Liu

Pages: 360-368 Published online on: 29 October 2014

Assessment of gene promoter G‑quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells

Matteo Nadai, Graziella Cimino‑Reale, Giovanna Sattin, Filippo Doria, Elena Butovskaya, Nadia Zaffaroni, Mauro Freccero, Manlio Palumbo, Sara N. Richter, Marco Folini

Pages: 369-380 Published online on: 23 October 2014

Long-term health-related quality of life after curative treatment for prostate cancer: A regional cross-sectional comparison of two standard treatment modalities

Marie Hjälm-Eriksson, Bo Lennernäs, Anders Ullén, Hemming Johansson, Jonas Hugosson, Sten Nilsson, Yvonne Brandberg

Pages: 381-388 Published online on: 29 October 2014

The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL

Qi Sun, Shingo Yogosawa, Yosuke Iizumi, Toshiyuki Sakai, Yoshihiro Sowa

Pages: 389-394 Published online on: 08 October 2014

Cks1 proteasomal turnover is a predominant mode of regulation in breast cancer cells: Role of key tyrosines and lysines

Vinayak Khattar, Jaideep V. Thottassery

Pages: 395-406 Published online on: 23 October 2014

Circulating tumor cells before and during follow-up after breast cancer surgery

Guus van Dalum, Gert Jan van der Stam, Arjan G.J. Tibbe, Bas Franken, Walter J.B. Mastboom, Ivan Vermes, Marco R. de Groot, Leon W.M.M. Terstappen

Pages: 407-413 Published online on: 06 October 2014

Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany

Elgar Susanne Quabius, Jochen Haag, André Kühnel, Hannes Henry, Anna Sophie Hoffmann, Tibor Görögh, Jürgen Hedderich, Matthias Evert, Achim G. Beule, Steffen Maune, Rainald Knecht, Attila Óvári, Martin Durisin, Florian Hoppe, Silke Tribius, Christoph Röcken, Petra Ambrosch, Markus Hoffmann

Pages: 414-422 Published online on: 07 October 2014

Multiple roles of extracellular fibroblast growth factors in lung cancer cells

Takahiro Suzuki, Hiroyuki Yasuda, Koji Funaishi, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Tetsuo Tani, Junko Hamamoto, Ayano Ohashi, Katsuhiko Naoki, Tomoko Betsuyaku, Kenzo Soejima

Pages: 423-429 Published online on: 21 October 2014

Long‑term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR‑mutant PC9 lung cancer cell line

Hideki Terai, Kenzo Soejima, Hiroyuki Yasuda, Takashi Sato, Katsuhiko  Naoki, Shinnosuke Ikemura, Daisuke Arai, Keiko Ohgino, Kota  Ishioka, Junko Hamamoto, Yae Kanai, Tomoko Betsuyaku

Pages: 430-436 Published online on: 29 October 2014
Journal Cover

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Volume 46 Issue 1

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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