Journal Articles

Long non‑coding RNAs drive metastatic progression in melanoma (Review)

Pouria Akhbari, Adrian Whitehouse, James R. Boyne

Pages: 2181-2186 Published online on: 01 October 2014

Significance of AKT in gastric cancer (Review)

Takamitsu Sasaki, Hiroki Kuniyasu

Pages: 2187-2192 Published online on: 26 September 2014

Cytoreductive prostatectomy: Evidence in support of a new surgical paradigm (Review)

Izak Faiena, Eric A. Singer, Chris Pumill, Isaac Y. Kim

Pages: 2193-2198 Published online on: 17 September 2014

Roles of F‑box proteins in human digestive system tumors (Review)

Jian Gong, Liang Lv, Jirong Huo

Pages: 2199-2207 Published online on: 29 September 2014
Open Access

Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer

Christina Lönnroth, Marianne Andersson, Annika G. Asting, Svante Nordgren, Kent Lundholm

Pages: 2208-2220 Published online on: 30 September 2014
Open Access

A phase I dose-escalation study to a predefined dose of a transforming growth factor-β1 monoclonal antibody (TβM1) in patients with metastatic cancer

Allen Cohn, Michael M. Lahn, Kristen E. Williams, Ann L. Cleverly, Celine Pitou, Sunil K. Kadam, Mark W. Farmen, Durisala Desaiah, Robert Raju, Paul Conkling, Donald Richards

Pages: 2221-2231 Published online on: 26 September 2014
Open Access

Expression and clinical significance of CXCR5/CXCL13 in human non‑small cell lung carcinoma

Rajesh Singh, Pranav Gupta, Goetz H. Kloecker, Shailesh Singh, James W. Lillard Jr

Pages: 2232-2240 Published online on: 30 September 2014
Open Access

A model of spontaneous mouse mammary tumor for human estrogen receptor- and progesterone receptor-negative breast cancer

Lixiang Zheng, Bugao Zhou, Xianming Meng, Weifeng Zhu, Airen Zuo, Xiaomin Wang, Runde Jiang, Shiping Yu

Pages: 2241-2249 Published online on: 17 September 2014
Open Access

Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers

Ramon G. Manzano, Elena M. Martinez-Navarro, Jeronimo Forteza, Antonio Brugarolas

Pages: 2250-2266 Published online on: 09 September 2014
Open Access

The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®)

Andreas K.A. Gaumann, Hannes C.A. Drexler, Sven A. Lang, Oliver Stoeltzing, Simone Diermeier‑Daucher, Elisabeth Buchdunger, Jeanette Wood, Guido Bold, Georg Breier

Pages: 2267-2277 Published online on: 29 September 2014

Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway

Ken Sadahira, Morihiko Sagawa, Tomonori Nakazato, Hideo Uchida, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima, Masahiro Kizaki

Pages: 2278-2286 Published online on: 15 September 2014

Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer

Tadayoshi Otsuki, Daisuke Fujimoto, Yasuo Hirono, Takanori Goi, Akio Yamaguchi

Pages: 2287-2294 Published online on: 15 September 2014

Comparison of standard-dose and half‑dose sorafenib therapy on clinical outcome in patients with unresectable hepatocellular carcinoma in field practice: A propensity score matching analysis

Hiroki Nishikawa, Yukio Osaki, Masatsugu Endo, Haruhiko Takeda, Kaoru Tsuchiya, Kouji Joko, Chikara Ogawa, Hiroyoshi Taniguchi, Etsuro Orito, Yasushi Uchida, Namiki Izumi

Pages: 2295-2302 Published online on: 16 September 2014

Kupffer cells decrease metastasis of colon cancer cells to the liver in the early stage

Hideki Matsumura, Tadashi Kondo, Koichi Ogawa, Takafumi Tamura, Kiyoshi Fukunaga, Soichiro Murata, Nobuhiro Ohkohchi

Pages: 2303-2310 Published online on: 18 September 2014

Effects of metformin on retinoblastoma growth in vitro and in vivo

Katarzyna Brodowska, Sofia Theodoropoulou, Melissa Meyer Zu Hörste, Eleftherios I. Paschalis, Kimio Takeuchi, Gordon Scott, David J. Ramsey, Elizabeth Kiernan, Mien Hoang, Joanna Cichy, Joan W. Miller, Evangelos S. Gragoudas, Demetrios G. Vavvas

Pages: 2311-2324 Published online on: 11 September 2014

Biphasic ER-α36-mediated estrogen signaling regulates growth of gastric cancer cells

Xuming Wang, Xuan Huang, Zhengqi Fu, Feng Zou, Yan Li, Zhaoyi Wang, Lijiang Liu

Pages: 2325-2330 Published online on: 17 September 2014

Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells

Soma Kundu, Tae Hyung Kim, Jung Hyun Yoon, Han-Seung Shin, Jaewon Lee, Jee H. Jung, Hyung Sik Kim

Pages: 2331-2340 Published online on: 17 September 2014

p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system

Meihui Xia, Huimei Yu, Shuang Gu, Ye Xu, Jing Su, Hongyan Li, Jinsong Kang, Manhua Cui

Pages: 2341-2348 Published online on: 24 September 2014

Identification of chemoradiation-resistant osteosarcoma stem cells using an imaging system for proteasome activity

Keisuke Tamari, Kazuhiko Hayashi, Hideshi Ishii, Yoshihiro Kano, Masamitsu Konno, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Takahito Fukusumi, Shinichiro Hasegawa, Hisataka Ogawa, Atsushi Hamabe, Masaaki Miyo, Kozo Noguchi, Yuji Seo, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa

Pages: 2349-2354 Published online on: 24 September 2014

Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo

Hong Chen, Yang Zou, Hong Yang, Jingjing Wang, Hong Pan

Pages: 2355-2364 Published online on: 09 September 2014

Cancer stem cells are enriched in Fanconi anemia head and neck squamous cell carcinomas

Jean Wu, Qingshan Mu, Varatharasa Thiviyanathan, Ananth Annapragada, Nadarajah Vigneswaran

Pages: 2365-2372 Published online on: 26 September 2014

Potential crosstalk of Ca2+-ROS-dependent mechanism involved in apoptosis of Kasumi-1 cells mediated by heme oxygenase-1 small interfering RNA

Sixi Wei, Yating Wang, Qixiang Chai, Qin Fang, Yaming Zhang, Jishi Wang

Pages: 2373-2384 Published online on: 17 September 2014

Silencing HIWI suppresses the growth, invasion and migration of glioma cells

Xiuyu Wang, Xiaoguang Tong, Hongmei Gao, Xiaoling Yan, Xinnv Xu, Shupeng Sun, Qiong Wang, Jinhuan Wang

Pages: 2385-2392 Published online on: 25 September 2014

Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondria‑dependent pathways of A375.S2 human melanoma cells

Yu‑Ping Hsiao, Chung-Hung Tsai, Ping‑Ping Wu, Shu‑Chun Hsu, Hsin‑Chung Liu, Yi‑Ping Huang, Jen‑Hung Yang, Jing‑Gung Chung

Pages: 2393-2402 Published online on: 30 September 2014

MicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinoma

Yang-Ki Minn, Da Hye Lee, Woo Jin Hyung, Ji Eun Kim, Junjeong Choi, Seung-Ho Yang, Hotaek Song, Beom Jin Lim, Se Hoon Kim

Pages: 2403-2410 Published online on: 26 September 2014

Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth

Zi-Xue Xuan, Lin-Na Li, Qi Zhang, Cheng-Wang Xu, De-Xuan Yang, Ye Yuan, Ying-Hong An, Shan-Shan Wang, Xiao-Wen Li, Shou-Jun Yuan

Pages: 2411-2420 Published online on: 01 October 2014

A potential regulatory loop between Lin28B:miR‑212 in androgen-independent prostate cancer

Emma Borrego-Diaz, Benjamin C. Powers, Vugar Azizov, Scott Lovell, Ruben Reyes, Bradley Chapman, Ossama Tawfik, Douglas McGregor, Francisco J. Diaz, Xinkun Wang, Peter Van Veldhuizen

Pages: 2421-2429 Published online on: 09 September 2014

P-Akt/miR‑200 signaling regulates epithelial-mesenchymal transition, migration and invasion in circulating gastric tumor cells

Dandan Yuan, Hongwei Xia, Yuchen Zhang, Liang Chen, Weibing Leng, Tie Chen, Qingjuan Chen, Qiulin Tang, Xianming Mo, Ming Liu, Feng Bi

Pages: 2430-2438 Published online on: 09 September 2014

Paclitaxel in combination with cetuximab exerts antitumor effect by suppressing NF-κB activity in human oral squamous cell carcinoma cell lines

Koji Harada, Tarannum Ferdous, Hiroaki Kobayashi, Yoshiya Ueyama

Pages: 2439-2445 Published online on: 17 September 2014

Bispecific anti‑CD3 x anti‑HER2 antibody mediates T cell cytolytic activity to HER2‑positive colorectal cancer in vitro and in vivo

Huamin Han, Juan Ma, Keming Zhang, Wei Li, Changzhen Liu, Yu Zhang, Ganlin Zhang, Pan Ma, Lei Wang, Ge Zhang, Hua Tao, Bin Gao

Pages: 2446-2454 Published online on: 18 September 2014

Monoclonal antibody G250 targeting CA Ⅸ: Binding specificity, internalization and therapeutic effects in a non‑renal cancer model

Miriam Zatovicova, Lenka Jelenska, Alzbeta Hulikova, Peter Ditte, Zuzana  Ditte, Lucia Csaderova, Eliska Svastova, Wolfgang Schmalix, Volker  Boettger, Paul Bevan, Jaromir Pastorek, Silvia Pastorekova

Pages: 2455-2467 Published online on: 17 September 2014

Visualization and characterization of cancer stem-like cells in cervical cancer

Kazuhiko Hayashi, Keisuke Tamari, Hideshi Ishii, Masamitsu Konno, Naohiro Nishida, Koichi Kawamoto, Jun Koseki, Takahito Fukusumi, Yoshihiro Kano, Shimpei Nishikawa, Masaaki Miyo, Kozo Noguchi, Hisataka Ogawa, Atsushi Hamabe, Yuji Seo, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa

Pages: 2468-2474 Published online on: 24 September 2014

Possible contribution of aminopeptidase N (APN/CD13) to migration and invasion of human osteosarcoma cell lines

Wenqing Liang, Bo Gao, Guojian Xu, Dong Weng, Minghua Xie, Yu Qian

Pages: 2475-2485 Published online on: 22 September 2014

miR‑494 is an independent prognostic factor and promotes cell migration and invasion in colorectal cancer by directly targeting PTEN

Hai‑Bing Sun, Xi Chen, Hong Ji, Tao Wu, Hong‑Wei Lu, Yan Zhang, Hua Li, Yi‑Ming Li

Pages: 2486-2494 Published online on: 22 September 2014

Alterations in the serum proteome profile during the development of ovarian cancer

Liping Sun, Li Li, Zhao Li, Shuhui Hong, Qifeng Yang, Xun Qu, Beihua Kong

Pages: 2495-2501 Published online on: 25 September 2014

CCR7 regulates cell migration and invasion through MAPKs in metastatic squamous cell carcinoma of head and neck

Fa‑Yu Liu, Jawad Safdar, Zhen‑Ning Li, Qi‑Gen Fang, Xu Zhang, Zhong‑Fei Xu, Chang‑Fu Sun

Pages: 2502-2510 Published online on: 25 September 2014

Methylation‑associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma

Ke‑Hong Chen, Jiang He, De‑Lin Wang, Jian‑Jia Cao, Mei‑Cai Li, Xiu‑Min Zhao, Xia Sheng, Wen‑Bin Li, Wu‑Jiang Liu

Pages: 2511-2521 Published online on: 30 September 2014

Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2

Megumi Maeda, Ying Chen, Hiroaki Hayashi, Naoko Kumagai-Takei, Hidenori Matsuzaki, Suni Lee, Yasumitsu Nishimura, Takemi Otsuki

Pages: 2522-2532 Published online on: 29 September 2014

Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9

Ki Rim Lee, Jong Seok Lee, Jeong Eun Song, Suk Jin Ha, Eock Kee Hong

Pages: 2533-2540 Published online on: 30 September 2014

HP1β suppresses metastasis of human cancer cells by decreasing the expression and activation of MMP2

Sang Ah Yi, Hyun‑Wook Ryu, Dong Hoon Lee, Jeung‑Whan Han, So Hee Kwon

Pages: 2541-2548 Published online on: 09 September 2014

Identification of a metabolic and canonical biomarker signature in Mexican HR+/HER2-, triple positive and triple-negative breast cancer patients

Silvia Cecilia Pacheco-Velázquez, Juan Carlos Gallardo-Pérez, José Luis Aguilar-Ponce, Patricia Villarreal, Luz Ruiz-Godoy, Manuel Pérez-Sánchez, Alvaro Marín-Hernández, Erika Ruiz-García, Abelardo Meneses-García, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez

Pages: 2549-2559 Published online on: 25 September 2014

Knockdown of β3GnT8 reverses 5‑fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine‑type N‑glycans

Li Shen, Meiyun Yu, Xu Xu, Liping Gao, Jianlong Ni, Zhiguo Luo, Shiliang Wu

Pages: 2560-2568 Published online on: 25 September 2014

Protective effects of deep sea water against doxorubicin‑induced cardiotoxicity in H9c2 cardiac muscle cells

Do‑Hyung Lee, Soyoung Kim, Kyung‑Soo Nam

Pages: 2569-2575 Published online on: 22 September 2014

Epigenetic silencing of miRNA‑9 is correlated with promoter‑proximal CpG island hypermethylation in gastric cancer in vitro and in vivo

Yan Li, Zhong Xu, Bo Li, Zhengzheng Zhang, Hongchun Luo, Yuanhu Wang, Zhizhong Lu, Xiaoling Wu

Pages: 2576-2586 Published online on: 23 September 2014

DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling

Dong Wang, Sheng Han, Rui Peng, Chenyu Jiao, Xing  Wang, Zeguang Han, Xiangcheng Li

Pages: 2596-2604 Published online on: 16 September 2014
Open Access

[Erratum] ERGO: A pilot study of ketogenic diet in recurrent glioblastoma

Johannes Rieger, Oliver Bähr, Gabriele D. Maurer, Elke Hattingen, Kea Franz, Daniel Brucker, Stefan Walenta, Ulrike Kämmerer, Johannes F. Coy, Michael Weller, Joachim P. Steinbach

Pages: 2605-2605 Published online on: 29 September 2014
Journal Cover

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Volume 45 Issue 6

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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