Open Access

Aspirin alleviates orthopedic implant‑associated infection

  • Authors:
    • Yi Jiang
    • Sheng‑Nan Wang
    • Hang‑Tian Wu
    • Han‑Jun Qin
    • Ming‑Liang Ren
    • Jian‑Chun Lin
    • Bin Yu
  • View Affiliations

  • Published online on: August 2, 2019     https://doi.org/10.3892/ijmm.2019.4298
  • Pages: 1281-1288
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Implant‑associated infection (IAI), a common condition marked by progressive inflammation and bone destruction, is mentally and financially devastating to those it affects, causing severe morbidity, prolonged hospital admissions, significant hospital costs and, in certain cases, mortality. Aspirin, a popular synthetic compound with a history of >100 years, is antipyretic, anti‑inflammatory and analgesic. It is the most active component of non‑steroidal anti‑inflammatory drugs. However, the effects of aspirin on IAI remain unknown. In the present study, an IAI animal model was used, in which a stainless steel pin coated with Staphylococcus aureus was implanted through the left shaft of the tibia in mice. The animals were then randomized into five groups and subjected respectively to IAI, IAI + 15 mg aspirin treatment, IAI + 30 mg aspirin treatment, IAI + 60 mg aspirin treatment and IAI + 120 mg aspirin treatment groups. Aspirin was injected intraperitoneally twice daily for 11 days. Micro‑CT and histological assays were performed to assess the effects of aspirin on IAI. It was found that aspirin reduced osteolysis and periosteal reaction, inhibited the activation of osteoclasts, promoted the activation of osteoblasts and facilitated healing of the infected fracture.

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October 2019
Volume 44 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
APA
Jiang, Y., Wang, S., Wu, H., Qin, H., Ren, M., Lin, J., & Yu, B. (2019). Aspirin alleviates orthopedic implant‑associated infection. International Journal of Molecular Medicine, 44, 1281-1288. https://doi.org/10.3892/ijmm.2019.4298
MLA
Jiang, Y., Wang, S., Wu, H., Qin, H., Ren, M., Lin, J., Yu, B."Aspirin alleviates orthopedic implant‑associated infection". International Journal of Molecular Medicine 44.4 (2019): 1281-1288.
Chicago
Jiang, Y., Wang, S., Wu, H., Qin, H., Ren, M., Lin, J., Yu, B."Aspirin alleviates orthopedic implant‑associated infection". International Journal of Molecular Medicine 44, no. 4 (2019): 1281-1288. https://doi.org/10.3892/ijmm.2019.4298