Open Access

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

  • Authors:
    • Jae‑Won Lee
    • Hyung Won Ryu
    • Su Ui Lee
    • Min‑Gu Kim
    • Ok‑Kyoung Kwon
    • Mun Ok Kim
    • Tae Kyu Oh
    • Jae Kyoung Lee
    • Tae Young Kim
    • Sang Woo Lee
    • Sangho Choi
    • Wan‑Yi Li
    • Kyung‑Seop Ahn
    • Sei‑Ryang Oh
  • View Affiliations

  • Published online on: June 20, 2019     https://doi.org/10.3892/ijmm.2019.4247
  • Pages: 949-959
  • Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pistacia weinmannifolia (PW) has been used in traditional Chinese medicine to treat headaches, dysentery, enteritis and influenza. However, PW has not been known for treating respiratory inflammatory diseases, including chronic obstructive pulmonary disease (COPD). The present in vitro analysis confirmed that PW root extract (PWRE) exerts anti‑inflammatory effects in phorbol myristate acetate‑ or tumor necrosis factor α (TNF‑α)‑stimulated human lung epithelial NCI‑H292 cells by attenuating the expression of interleukin (IL)‑8, IL‑6 and Mucin A5 (MUC5AC), which are closely associated with the pulmonary inflammatory response in the pathogenesis of COPD. Thus, the aim of the present study was to evaluate the protective effect of PWRE on pulmonary inflammation induced by cigarette smoke (CS) and lipopolysaccharide (LPS). Treatment with PWRE significantly reduced the quantity of neutrophils and the levels of inflammatory molecules and toxic molecules, including tumor TNF‑α, IL‑6, IL‑8, monocyte chemoattractant protein‑1, neutrophil elastase and reactive oxygen species, in the bronchoalveolar lavage fluid of mice with CS‑ and LPS‑induced pulmonary inflammation. PWRE also attenuated the influx of inflammatory cells in the lung tissues. Furthermore, PWRE downregulated the activation of nuclear factor‑κB and the expression of phosphodiesterase 4 in the lung tissues. Therefore, these findings suggest that PWRE may be a valuable adjuvant treatment for COPD.
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September-2019
Volume 44 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos
Lee J, Ryu HW, Lee SU, Kim M, Kwon O, Kim MO, et al: Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation. Int J Mol Med 44: 949-959, 2019
APA
Lee, J., Ryu, H.W., Lee, S.U., Kim, M., Kwon, O., Kim, M.O. ... Oh, S. (2019). Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation. International Journal of Molecular Medicine, 44, 949-959. https://doi.org/10.3892/ijmm.2019.4247
MLA
Lee, J., Ryu, H. W., Lee, S. U., Kim, M., Kwon, O., Kim, M. O., Oh, T. K., Lee, J. K., Kim, T. Y., Lee, S. W., Choi, S., Li, W., Ahn, K., Oh, S."Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation". International Journal of Molecular Medicine 44.3 (2019): 949-959.
Chicago
Lee, J., Ryu, H. W., Lee, S. U., Kim, M., Kwon, O., Kim, M. O., Oh, T. K., Lee, J. K., Kim, T. Y., Lee, S. W., Choi, S., Li, W., Ahn, K., Oh, S."Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation". International Journal of Molecular Medicine 44, no. 3 (2019): 949-959. https://doi.org/10.3892/ijmm.2019.4247