Open Access

Anti‑photoaging effect of fermented agricultural by‑products on ultraviolet B‑irradiated hairless mouse skin

  • Authors:
    • Sun‑Il Choi
    • Tae‑Dong Jung
    • Bong‑Yeon Cho
    • Seung‑Hyun Choi
    • Wan‑Sup Sim
    • Xionggao Han
    • Sang Jong Lee
    • Young‑Cheul Kim
    • Ok‑Hwan Lee
  • View Affiliations

  • Published online on: June 12, 2019     https://doi.org/10.3892/ijmm.2019.4242
  • Pages: 559-568
  • Copyright: © Choi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Processed products from agricultural produce generate a large number of agricultural by‑products that contain a number of functional substances. These are often discarded owing to the lack of suitable processing methods. The present study investigated the anti‑photoaging properties of fermented rice bran (FRB), soybean cake (FSB) and sesame seed cake (FSC) on ultraviolet B (UVB)‑irradiated hairless mouse skin. Results indicated that the oral administration of FRB, FSB and FSC effectively inhibited the UVB irradiation‑induced expression of matrix metalloproteinase (MMP)‑2, MMP‑9, MMP‑3 and MMP‑13. Reverse transcription‑quantitative polymerase chain reaction results also demonstrated that FRB, FSB and FSC significantly inhibited the UVB‑induced expression of the genes encoding tumor necrosis factor‑α, inducible nitric oxide synthase, interleukin (IL)‑6 and IL‑1β when compared with the UVB‑vehicle group (P<0.05). Additionally, collagen degradation and mast cell infiltration were reduced in hairless mouse skin. Furthermore, UVB‑induced wrinkle formation was also significantly reduced in mouse skin compared with the UVB‑vehicle group (P<0.05). These results reveal that fermented agricultural by‑products may serve as potential functional materials with anti‑photoaging activities.
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August-2019
Volume 44 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos
Choi S, Jung T, Cho B, Choi S, Sim W, Han X, et al: Anti‑photoaging effect of fermented agricultural by‑products on ultraviolet B‑irradiated hairless mouse skin. Int J Mol Med 44: 559-568, 2019
APA
Choi, S., Jung, T., Cho, B., Choi, S., Sim, W., Han, X. ... Lee, O. (2019). Anti‑photoaging effect of fermented agricultural by‑products on ultraviolet B‑irradiated hairless mouse skin. International Journal of Molecular Medicine, 44, 559-568. https://doi.org/10.3892/ijmm.2019.4242
MLA
Choi, S., Jung, T., Cho, B., Choi, S., Sim, W., Han, X., Lee, S. J., Kim, Y., Lee, O."Anti‑photoaging effect of fermented agricultural by‑products on ultraviolet B‑irradiated hairless mouse skin". International Journal of Molecular Medicine 44.2 (2019): 559-568.
Chicago
Choi, S., Jung, T., Cho, B., Choi, S., Sim, W., Han, X., Lee, S. J., Kim, Y., Lee, O."Anti‑photoaging effect of fermented agricultural by‑products on ultraviolet B‑irradiated hairless mouse skin". International Journal of Molecular Medicine 44, no. 2 (2019): 559-568. https://doi.org/10.3892/ijmm.2019.4242