Open Access

Nicorandil effects on platelet function, Hs-CRP, MMP-9 and myocardial antioxidation in patients with unstable angina

  • Authors:
    • Ruijun Peng
    • Xili Yang
    • Xi Liang
  • View Affiliations

  • Published online on: August 20, 2019     https://doi.org/10.3892/etm.2019.7918
  • Pages: 3095-3099
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nicorandil effects on platelet activation and myocardial antioxidant function in patients with unstable angina were studied. A total of 157 patients with unstable angina in the First People's Hospital of Foshan were selected and divided into experimental and control group. Patients in experimental group were treated with conventional drugs and nicorandil (15 min/day), t.i.d., for 21 days as one course of treatment, while those in control group were treated with conventional drugs. After treatment, serum indexes were detected and compared between the two groups of patients. Compared with that in control group, the platelet function of patients in the experimental group was significantly improved, and there was a statistically significant difference (P<0.05). Serum anti-oxidation factors in both groups were increased after treatment, and they were increased more significantly in experimental group (P<0.05). Serum inflammatory factors, high-sensitivity C-reactive protein and matrix metalloproteinase-9, also declined significantly in the experimental group. Nicorandil reduces inflammatory response and promotes stability of myocardial function in the treatment of unstable angina.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Peng, R., Yang, X., & Liang, X. (2019). Nicorandil effects on platelet function, Hs-CRP, MMP-9 and myocardial antioxidation in patients with unstable angina. Experimental and Therapeutic Medicine, 18, 3095-3099. https://doi.org/10.3892/etm.2019.7918
MLA
Peng, R., Yang, X., Liang, X."Nicorandil effects on platelet function, Hs-CRP, MMP-9 and myocardial antioxidation in patients with unstable angina". Experimental and Therapeutic Medicine 18.4 (2019): 3095-3099.
Chicago
Peng, R., Yang, X., Liang, X."Nicorandil effects on platelet function, Hs-CRP, MMP-9 and myocardial antioxidation in patients with unstable angina". Experimental and Therapeutic Medicine 18, no. 4 (2019): 3095-3099. https://doi.org/10.3892/etm.2019.7918