Open Access

Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections

  • Authors:
    • Yuan Li
    • Xin Zhang
    • Lixin Chen
    • Bo Yang
    • Rubo Sui
  • View Affiliations

  • Published online on: August 16, 2019     https://doi.org/10.3892/etm.2019.7913
  • Pages: 2885-2892
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate whether the cerebellar fastigial nucleus (FN) is involved in post‑stroke depression (PSD), and to observe the effect of direct cerebellar‑hypothalamic γ‑aminobutyric acid (GABA)ergic and glutamatergic projections on PSD, in order to understand the mechanisms underlying the cerebellar modulation of mood and emotion. Healthy Sprague‑Dawley rats were randomly divided into five groups: Sham‑operated, Stroke, PSD, FN lesion, and decussation of superior cerebellar peduncle (XSCP) lesion groups. Sham surgery was performed in animals of the Sham group (n=6). The rats in the other four groups (n=6 for each group) underwent middle cerebral artery occlusion. The rats were examined twice a week in an open field test. In addition, the expression of cytokines in hippocampal tissues, and the content of glutamate and GABA in the lateral hypothalamic area (LHA) were measured. The results showed that scores corresponding to the behavioral signs of depression were decreased in the PSD, FN lesion and XSCP lesion groups. In addition, the mRNA levels of tumor necrosis factor‑α, interleukin (IL)‑6, and IL‑1β in the hippocampus of the PSD, FN lesion and XSCP lesion groups were significantly increased. The GABA and glutamate content in the LHA were also decreased significantly in the PSD, FN lesion and XSCP lesion groups. Taken together, the findings of the present study indicated that the cerebellar FN may be involved in PSD through the direct cerebellar‑hypothalamic glutamatergic and GABAergic projections.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Li, Y., Zhang, X., Chen, L., Yang, B., & Sui, R. (2019). Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections. Experimental and Therapeutic Medicine, 18, 2885-2892. https://doi.org/10.3892/etm.2019.7913
MLA
Li, Y., Zhang, X., Chen, L., Yang, B., Sui, R."Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections". Experimental and Therapeutic Medicine 18.4 (2019): 2885-2892.
Chicago
Li, Y., Zhang, X., Chen, L., Yang, B., Sui, R."Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2885-2892. https://doi.org/10.3892/etm.2019.7913