Open Access

Investigation of leukocyte RHO/ROCK gene expressions in patients with non‑valvular atrial fibrillation

  • Authors:
    • Irfan V. Düzen
    • Fethi Yavuz
    • Ertan Vuruskan
    • Erhan Saracoglu
    • Fatih Poyraz
    • Yusuf Cekici
    • Hayri Alıcı
    • Hüseyin Göksülük
    • Basar Candemir
    • Murat Sucu
    • Abdullah T. Demiryürek
  • View Affiliations

  • Published online on: August 20, 2019     https://doi.org/10.3892/etm.2019.7929
  • Pages: 2777-2782
  • Copyright: © Düzen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Atrial fibrillation (AF) is an arrhythmia caused by disorganized electrical activity in the atria, and it is an important cause of mortality and morbidity. There is a limited data about Rho/Rho‑kinase (ROCK) pathway contribute to AF development. The aim of the present study was to elucidate leukocyte RHO/ROCK gene expressions in patients with non‑valvular AF (NVAF). A total of 37 NVAF patients and 47 age and sex‑matched controls were included in this study. mRNA was extracted from leukocytes, and real‑time polymerase chain reaction was used for gene expression analysis. A marked increase in ROCK1 and ROCK2 gene expressions in patients with NVAF was observed (P<0.0001). The present study detected significant elevations in RHOBTB2, RND3 (RHOE), RHOC, RHOG, RHOH, RAC3, RHOB, RHOD, RHOV, RHOBTB1, RND2, RND1 and RHOJ gene expressions (P<0.01). However, there were marked decreases in CDC42, RAC2, and RHOQ gene expressions in patients with NVAF. No significant modifications were seen in the other Rho GTPase proteins RHOA, RAC1, RHOF, RHOU and RHOBTB3. To the best of our knowledge, the present study is the first to provide data that gene expression of leukocyte RHO/ROCK may contribute to the NVAF pathogenesis through activated leukocytes, which promotes the immune or inflammatory cascade.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Düzen, I.V., Yavuz, F., Vuruskan, E., Saracoglu, E., Poyraz, F., Cekici, Y. ... Demiryürek, A.T. (2019). Investigation of leukocyte RHO/ROCK gene expressions in patients with non‑valvular atrial fibrillation. Experimental and Therapeutic Medicine, 18, 2777-2782. https://doi.org/10.3892/etm.2019.7929
MLA
Düzen, I. V., Yavuz, F., Vuruskan, E., Saracoglu, E., Poyraz, F., Cekici, Y., Alıcı, H., Göksülük, H., Candemir, B., Sucu, M., Demiryürek, A. T."Investigation of leukocyte RHO/ROCK gene expressions in patients with non‑valvular atrial fibrillation". Experimental and Therapeutic Medicine 18.4 (2019): 2777-2782.
Chicago
Düzen, I. V., Yavuz, F., Vuruskan, E., Saracoglu, E., Poyraz, F., Cekici, Y., Alıcı, H., Göksülük, H., Candemir, B., Sucu, M., Demiryürek, A. T."Investigation of leukocyte RHO/ROCK gene expressions in patients with non‑valvular atrial fibrillation". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2777-2782. https://doi.org/10.3892/etm.2019.7929