Plasma levels and expression of interleukin‑37 in patients with immune thrombocytopenia

  • Authors:
    • Feng Zhang
    • Xiao‑Juan Zhu
    • Xiao‑Jing Zhu
    • Yan‑Xia Liu
    • Ting Yuan
    • Qing‑Min Yao
  • View Affiliations

  • Published online on: July 30, 2019     https://doi.org/10.3892/etm.2019.7824
  • Pages: 2739-2745
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Abstract

Interleukin (IL)‑37 has an important role in autoimmune diseases by suppressing immunity and inflammation; however, the role of IL‑37 in immune thrombocytopenia (ITP) has remained largely elusive. The present study aimed to investigate the expression of IL‑37 and its potential role in the pathogenesis of ITP. The plasma levels and expression of IL‑37 in the peripheral blood mononuclear cells of patients with active ITP, ITP patients in remission and healthy controls were measured by ELISA and reverse transcription‑quantitative PCR, respectively. The levels of IL‑37 in patients with ITP treated with and without glucocorticoids were also determined by ELISA. Specific anti‑platelet glycoprotein (GP)IIb/IIIa and/or GPIb/IX autoantibodies were assayed by modified monoclonal antibody‑specific immobilization of platelet antigens. The mean value of plasma IL‑37 in ITP patients was slightly higher than that in healthy controls, but this was not statistically significant. There was no correlation between IL‑37 and anti‑platelet autoantibodies, and no significant difference in the IL‑37 concentration was identified between patients treated with and without glucocorticoids. In addition, the correlation between IL‑37 and the platelet count was analyzed, with no statistical significance observed. It was therefore concluded that IL‑37 may not have a pivotal role in the development of ITP. However, the lack of significant differences may be due to the limited number of patients in different groups. A larger number of ITP patients should be enrolled in the future work and achieve more accurate results.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Zhang, F., Zhu, X., Zhu, X., Liu, Y., Yuan, T., & Yao, Q. (2019). Plasma levels and expression of interleukin‑37 in patients with immune thrombocytopenia. Experimental and Therapeutic Medicine, 18, 2739-2745. https://doi.org/10.3892/etm.2019.7824
MLA
Zhang, F., Zhu, X., Zhu, X., Liu, Y., Yuan, T., Yao, Q."Plasma levels and expression of interleukin‑37 in patients with immune thrombocytopenia". Experimental and Therapeutic Medicine 18.4 (2019): 2739-2745.
Chicago
Zhang, F., Zhu, X., Zhu, X., Liu, Y., Yuan, T., Yao, Q."Plasma levels and expression of interleukin‑37 in patients with immune thrombocytopenia". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2739-2745. https://doi.org/10.3892/etm.2019.7824