Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy

  • Authors:
    • Xianfeng Qu
    • Xiao Chen
    • Qingqing Shi
    • Xiaofei Wang
    • Dongguo Wang
    • Li Yang
  • View Affiliations

  • Published online on: August 2, 2019     https://doi.org/10.3892/etm.2019.7846
  • Pages: 2719-2725
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Abstract

The rising incidence and complications of diabetes constitutes a major public health issue. The mortality rate of diabetes‑induced myocardial ischemia/reperfusion (I/R) injury is significantly elevated. Resveratrol (RSV) is a naturally occurring polyphenol considered to be a potent cardioprotective compound. The aim of the present study was to explore the function and molecular mechanism of RSV on diabetes‑induced myocardial I/R injury. Left anterior descending coronary artery ligation was performed to stimulate myocardial I/R injury in streptozotocin‑induced diabetic rats. Heart electrical activity was monitored through an electrocardiogram to confirm successful models. The myocardial infarct volume was detected via 2,3,5‑triphenyltetrazolium chloride staining. Western blotting was employed to examine the levels of autophagy markers. It was found that the injection of RSV mitigated the ischemia‑ or I/R injury‑induced myocardial damage on hemodynamic function and infarct size, but the autophagy inhibitor 3‑methyladenine significantly blocked the function of RSV. Furthermore, the application of RSV significantly enhanced the expression of Beclin‑1 and LC‑3II but inhibited the serum levels of tumor necrosis factor‑α and interleukin‑6. These findings revealed an alleviating effect of RSV on diabetes‑induced myocardial I/R injury and provided new evidence for the successful application of RSV on the diabetic myocardium.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Qu, X., Chen, X., Shi, Q., Wang, X., Wang, D., & Yang, L. (2019). Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy. Experimental and Therapeutic Medicine, 18, 2719-2725. https://doi.org/10.3892/etm.2019.7846
MLA
Qu, X., Chen, X., Shi, Q., Wang, X., Wang, D., Yang, L."Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy". Experimental and Therapeutic Medicine 18.4 (2019): 2719-2725.
Chicago
Qu, X., Chen, X., Shi, Q., Wang, X., Wang, D., Yang, L."Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2719-2725. https://doi.org/10.3892/etm.2019.7846