The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study
- Alkan Sakar
- Tuna Bilecik
- Burhan Mayir
- Tahir Oruç
Affiliations: Department of General Surgery, Kepez State Hospital, Antalya 17110, Turkey, Department of General Surgery, School of Medicine, VM Mersin Medical Park Hospital, Istinye University, Mersin 33200, Turkey, Department of General Surgery, Antalya Training and Research Hospital, Antalya 07010, Turkey
- Published online on: August 2, 2019 https://doi.org/10.3892/etm.2019.7842
Copyright: © Sakar
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Staple‑line bleeding and leakage is a life‑threatening complication in obese patients following laparoscopic sleeve gastrectomy. The aim of this study was to examine the potential effects of Ankaferd blood stopper (ABS) and Fibrin Sealant (FS; Tisseel®) on sleeve gastrectomy staple‑line healing in an experimental animal model. A total of 30 Wistar albino female rats were divided into three groups and were subjected to sleeve gastrectomy with linear stapling. Group A (control group) had nothing administered, Group B was administered FS on the staple‑line, and Group C was administered ABS on the staple‑line following sleeve gastrectomy. After sacrifice on postoperative day 5, anastomotic burst pressure, tissue hydroxyproline levels and histopathological parameters were measured. The results revealed that group C had the highest mean bursting pressure level. However, the values of this parameter were not found to differ significantly between the groups (P>0.05). Group B and C had a similar hydroxyproline levels but increased compared with group A (P<0.001). Histopathological parameters were similar between the groups, except macrophage scores in group C. In the present experimental study, ABS was demonstrated to improve gastric‑sleeved staple‑line healing compared with FS. ABS may be used as a novel reinforcement agent in bariatric surgery.