Open Access

The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study

  • Authors:
    • Alkan Sakar
    • Tuna Bilecik
    • Burhan Mayir
    • Tahir Oruç
  • View Affiliations

  • Published online on: August 2, 2019     https://doi.org/10.3892/etm.2019.7842
  • Pages: 2519-2523
  • Copyright: © Sakar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Staple‑line bleeding and leakage is a life‑threatening complication in obese patients following laparoscopic sleeve gastrectomy. The aim of this study was to examine the potential effects of Ankaferd blood stopper (ABS) and Fibrin Sealant (FS; Tisseel®) on sleeve gastrectomy staple‑line healing in an experimental animal model. A total of 30 Wistar albino female rats were divided into three groups and were subjected to sleeve gastrectomy with linear stapling. Group A (control group) had nothing administered, Group B was administered FS on the staple‑line, and Group C was administered ABS on the staple‑line following sleeve gastrectomy. After sacrifice on postoperative day 5, anastomotic burst pressure, tissue hydroxyproline levels and histopathological parameters were measured. The results revealed that group C had the highest mean bursting pressure level. However, the values of this parameter were not found to differ significantly between the groups (P>0.05). Group B and C had a similar hydroxyproline levels but increased compared with group A (P<0.001). Histopathological parameters were similar between the groups, except macrophage scores in group C. In the present experimental study, ABS was demonstrated to improve gastric‑sleeved staple‑line healing compared with FS. ABS may be used as a novel reinforcement agent in bariatric surgery.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Sakar, A., Bilecik, T., Mayir, B., & Oruç, T. (2019). The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study. Experimental and Therapeutic Medicine, 18, 2519-2523. https://doi.org/10.3892/etm.2019.7842
MLA
Sakar, A., Bilecik, T., Mayir, B., Oruç, T."The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study". Experimental and Therapeutic Medicine 18.4 (2019): 2519-2523.
Chicago
Sakar, A., Bilecik, T., Mayir, B., Oruç, T."The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2519-2523. https://doi.org/10.3892/etm.2019.7842