Role and effective therapeutic target of gut microbiota in NAFLD/NASH (Review)

  • Authors:
    • Qun Liu
    • Shousheng Liu
    • Lizhen Chen
    • Zhenzhen Zhao
    • Shuixian Du
    • Quanjiang Dong
    • Yongning Xin
    • Shiying Xuan
  • View Affiliations

  • Published online on: July 17, 2019     https://doi.org/10.3892/etm.2019.7781
  • Pages: 1935-1944
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Abstract

Non‑alcoholic fatty liver disease (NAFLD), the most prevalent chronic liver disease in the world, is affected by numerous extrinsic and intrinsic factors, including lifestyle, environment, diet, genetic susceptibility, metabolic syndrome and gut microbiota. Accumulating evidence has proven that gut dysbiosis is significantly associated with the development and progression of NAFLD, and several highly variable species in gut microbiota have been identified. The gut microbiota contributes to NAFLD by abnormal regulation of the liver‑gut axis, gut microbial components and microbial metabolites, and affects the secretion of bile acids. Due to the key role of the gut microbiota in NAFLD, it has been regarded as a potential target for the pharmacological and clinical treatment of NAFLD. The present review provides a systematic summary of the characterization of gut microbiota and the significant association between the gut microbiota and NAFLD. The possible mechanisms of how the gut microbiota is involved in promoting the development and progression of NAFLD were also discussed. In addition, the potential therapeutic methods for NAFLD based on the gut microbiota were summarized.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Liu, Q., Liu, S., Chen, L., Zhao, Z., Du, S., Dong, Q. ... Xuan, S. (2019). Role and effective therapeutic target of gut microbiota in NAFLD/NASH (Review). Experimental and Therapeutic Medicine, 18, 1935-1944. https://doi.org/10.3892/etm.2019.7781
MLA
Liu, Q., Liu, S., Chen, L., Zhao, Z., Du, S., Dong, Q., Xin, Y., Xuan, S."Role and effective therapeutic target of gut microbiota in NAFLD/NASH (Review)". Experimental and Therapeutic Medicine 18.3 (2019): 1935-1944.
Chicago
Liu, Q., Liu, S., Chen, L., Zhao, Z., Du, S., Dong, Q., Xin, Y., Xuan, S."Role and effective therapeutic target of gut microbiota in NAFLD/NASH (Review)". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1935-1944. https://doi.org/10.3892/etm.2019.7781