Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells

  • Authors:
    • Jae Young Shin
    • Denis Nchang Che
    • Byoung Ok Cho
    • Hyun Ju Kang
    • Jisu Kim
    • Seon Il Jang
  • View Affiliations

  • Published online on: July 1, 2019     https://doi.org/10.3892/etm.2019.7721
  • Pages: 1914-1920
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Abstract

Commiphora myrrha (Myrrh) is widely recognized for its anti‑inflammatory and antimicrobial properties, which are utilized for the treatment of oral ulcers, gingivitis, sinusitis, glomerulonephritis, brucellosis and a variety of skin disorders. The current study aimed to assess whether myrrh modulates itch‑associated interleukin (IL)‑31 cytokine production and histamine release in stimulated human mast cells (HMC‑1). To realize this, molecular biology techniques including real‑time quantitiative PCR, western blotting and ELISA were employed. The results indicated that Myrrh successfully suppressed phorbol myristate acetate and calcium ionophore‑stimulated mRNA expression, and reduced the production of IL‑31 in HMC‑1 cells. In addition, myrrh served as a suppressor of extracellular signal‑regulated kinase and NF‑κB activation, indicating its mechanism in the prevention of HMC‑1 cell IL‑31 production. Myrrh also prevented the release of histamine in HMC‑1 cells. Whilst the present study awaits in vivo support, the pharmacological actions of myrrh provide new indications as to its potential applicability for itch treatment, which cannot be treated with histamine receptor blockers alone.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Shin, J.Y., Che, D.N., Cho, B.O., Kang, H.J., Kim, J., & Jang, S.I. (2019). Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells. Experimental and Therapeutic Medicine, 18, 1914-1920. https://doi.org/10.3892/etm.2019.7721
MLA
Shin, J. Y., Che, D. N., Cho, B. O., Kang, H. J., Kim, J., Jang, S. I."Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells". Experimental and Therapeutic Medicine 18.3 (2019): 1914-1920.
Chicago
Shin, J. Y., Che, D. N., Cho, B. O., Kang, H. J., Kim, J., Jang, S. I."Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1914-1920. https://doi.org/10.3892/etm.2019.7721