Efficacy of intravenous lidocaine in improving post‑operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery

  • Authors:
    • Tao Wang
    • Hui Liu
    • Jian Hong Sun
    • Lin Wang
    • Jian You Zhang
  • View Affiliations

  • Published online on: April 17, 2019     https://doi.org/10.3892/etm.2019.7497
  • Pages: 4723-4729
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Post‑operative nausea and vomiting (PONV) is a major peri‑operative complication. It has numerous adverse consequences that seriously affect the post‑operative recovery of patients. The aim of the present study was to investigate the efficacy of intravenous lidocaine in improving PONV and recovery after laparoscopic gynaecological surgery. A total of 40 patients were randomly assigned to 2 groups: Group L (lidocaine group) and Group C (control group). The patients in Group L received intravenous lidocaine throughout the operation, while patients in Group C were given a saline infusion. Vital signs, recovery time, extubation time, dosage of remifentanil, first flatus time and defecation time of each patient were recorded. The incidence of PONV after surgery was also recorded. The recovery of the patients was evaluated by using the quality of recovery score (QoR‑40). The total dose of remifentanil was significantly lower in Group L (P<0.05). However, the recovery time and extubation time were shorter in Group C (P<0.05). The first flatus time and defecation time were longer in Group C (P<0.05). The mean arterial pressure and heart rate in Group L were lower and more stable (P<0.05). At 6 h after surgery, the incidence of PONV was significantly lower in Group L vs. that in Group C (P<0.05). The QoR‑40 score in Group C was significantly lower at 1 and 3 days after the operation compared with that in Group C (P<0.05). In conclusion, intravenous lidocaine administered to patients undergoing laparoscopic gynaecological surgery may reduce PONV and supports their early recovery [trial registration number in Chinese Clinical Trial Registry: ChiCTR‑IOR‑17010782 (March 5, 2017)].

References

1 

Buia A, Stockhausen F and Hanisch E: Laparoscopic surgery: A qualified systematic review. World J Methodol. 5:238–254. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Gan TJ: Risk factors for postoperative nausea and vomiting. Anesth Analg. 102:1884–1898. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Franck M, Radtke FM, Apfel CC, Kuhly R, Baumeyer A, Brandt C, Wernecke KD and Spies CD: Documentation of post-operative nausea and vomiting in routine clinical practice. J Int Med Res. 38:1034–1041. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Choi DH, Ko JS, Ahn HJ and Kim JA: A Korean predictive model for postoperative nausea and vomiting. J Korean Med Sci. 20:811–815. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Apfel CC, Heidrich FM, Jukar-Rao S, Jalota L, Hornuss C, Whelan RP, Zhang K and Cakmakkaya OS: Evidence-based analysis of risk factors for postoperative nausea and vomiting. Br J Anaesth. 109:742–753. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Wu O, Belo SE and Koutsoukos G: Additive antiemetic efficacy of prophylactic ondansetron with droperidol in out-patient gynecological laparoscopy. Can J Anaesth. 47:529–536. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Achuthan S, Singh I, Varthya SB, Srinivasan A, Chakrabarti A and Hota D: Gabapentin prophylaxis for postoperative nausea and vomiting in abdominal surgeries: A quantitative analysis of evidence from randomized controlled clinical trials. Br J Anaesth. 114:588–597. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Apfel CC: Postoperative nausea and vomiting. Miller's anesthesia. 7th. Miller RD: Churchill Livingstone; Philadelphia, PA: pp. 2729–2755. 2010, View Article : Google Scholar

9 

Swaika S, Pal A, Chatterjee S, Saha D and Dawar N: Ondansetron, ramosetron, or palonosetron: Which is a better choice of antiemetic to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy? Anesth Essays Res. 5:182–186. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Shaikh SI, Nagarekha D, Hegade G and Marutheesh M: Postoperative nausea and vomiting: A simple yet complex problem. Anesth Essays Res. 10:388–396. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Herminghaus A, Wachowiak M, Wilhelm W and Gottschalk A, Eggert K and Gottschalk A: Intravenous administration of lidocaine for perioperative analgesia. Review and recommendations for practical usage. Anaesthesist. 60:152–160. 2011.(In German). View Article : Google Scholar : PubMed/NCBI

12 

Jendoubi A, Naceur IB, Bouzouita A, Trifa M, Ghedira S, Chebil M and Houissa M: A comparison between intravenous lidocaine and ketamine on acute and chronic pain after open nephrectomy: A prospective, double-blind, randomized, placebo-controlled study. Saudi J Anaesth. 11:177–184. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Weibel S, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, Eberhart LH, Poepping DM, Afshari A and Kranke P: Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: A systematic review with trial sequential analysis. Br J Anaesth. 116:770–783. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Tikuišis R, Miliauskas P, Samalavičius NE, Žurauskas A, Samalavičius R and Zabulis V: Intravenous lidocaine for post-operative pain relief after hand-assisted laparoscopic colon surgery: A randomized, placebo-controlled clinical trial. Tech Coloproctol. 18:373–380. 2014. View Article : Google Scholar : PubMed/NCBI

15 

McKay A, Gottschalk A, Ploppa A, Durieux ME and Groves DS: Systemic lidocaine decreased the perioperative opioid analgesic requirements but failed to reduce discharge time after ambulatory surgery. Anesth Analg. 109:1805–1808. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML and Joris JL: Intravenous lidocaine infusion facilitates acute rehabilitation laparoscopic colectomy. Anesthesiology. 106:11–18. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Lauwick S, Kim DJ, Mistraletti G and Carli F: Functional walking capacity as an outcome measure of laparoscopic prostatectomy: The effect of lidocaine infusion. Br J Anaesth. 103:213–219. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Lauwick S, Kim DJ, Michelagnoli G, Mistraletti G, Feldman L, Fried G and Carli F: Intraoperative infusion of lidocaine reduces postoperative fentanyl requirements in patients undergoing laparoscopic cholecystectomy. Can J Anaesth. 55:754–760. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Grady MV, Mascha E, Sessler DI and Kurz A: The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy. Anesth Analg. 115:1078–1084. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Myles PS, Weitkamp B, Jones K, Melick J and Hensen S: Validity and reliability of a postoperative quality of recovery score: The QoR-40. Br J Anaesth. 84:11–15. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Gornall BF, Myles PS, Smith CL, Burke JA, Leslie K, Pereira MJ, Bost JE, Kluivers KB, Nilsson UG, Tanaka Y and Forbes A: Measurement of quality of recovery using the QoR-40: A quantitative systematic review. Br J Anaesth. 111:161–169. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Aronson WL, McAuliffe MS and Miller K: Variability in the American society of anesthesiologists physical status classification scale. AANA J. 71:265–274. 2003.PubMed/NCBI

23 

Ramsay MA, Savege TM, Simpson BR and Goodwin R: Controlled sedation with alphaxalone-alphadolone. Br Med J. 2:656–659. 1974. View Article : Google Scholar : PubMed/NCBI

24 

Carlsson AM: Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Pain. 16:87–101. 1983. View Article : Google Scholar : PubMed/NCBI

25 

Eberhart LH, Seeling W, Ulrich B, Morin AM and Georgieff M: Dimenhydrinate and metoclopramide alone or in combination for prophylaxis of PONV. Can J Anaesth. 47:780–185. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Phillips C, Brookes CD, Rich J, Arbon J and Turvey TA: Postoperative nausea and vomiting following orthognathic surgery. Int J Oral Maxillofac Surg. 44:745–751. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Sinclair DR, Chung F and Mezei G: Can postoperative nausea and vomiting be predicted? Anesthesiology. 91:109–118. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Cardoso FC and Lewis RJ: Sodium channels and pain: From toxins to therapies. Br J Pharmacol. 175:2138–2157. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Lauretti GR: Mechanisms of analgesia of intravenous lidocaine. Rev Bras Anestesiol. 58:280–286. 2008.(In English). View Article : Google Scholar : PubMed/NCBI

30 

Nakhli MS, Kahloul M, Guizani T, Zedini C, Chaouch A and Naija W: Intravenous lidocaine as adjuvant to general anesthesia in renal surgery. Libyan J Med. 13:14334182018. View Article : Google Scholar : PubMed/NCBI

31 

Kalso E: Sodium channel blockers in neuropathic pain. Curr Pharm Des. 11:3005–3011. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Kawamata M, Sugino S, Narimatsu E, Yamauchi M, Kiya T, Furuse S and Namiki A: Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat. Pain. 122:68–80. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Hahnenkamp K, Durieux ME, Hahnenkamp A, Schauerte SK, Hoenemann CW, Vegh V, Theilmeier G and Hollmann MW: Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: Role of protein kinase C. Br J Anaesth. 96:77–87. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Sugimoto M, Uchida I and Mashimo T: Local anaesthetics have different mechanisms and sites of action at the recombinant N-methyl-D aspartate (NMDA) receptors. Br J Pharmacol. 138:876–882. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Yousefshahi F, Predescu O and Asenjo JF: The efficacy of systemic lidocaine in the management of chronic pain: A literature review. Anesth Pain Med. 7:e447322017. View Article : Google Scholar : PubMed/NCBI

36 

Yardeni IZ, Beilin B, Mayburd E, Levinson Y and Bessler H: The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anesth Analg. 109:1464–1469. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Hans GA, Lauwick SM, Kaba A, Bonhomme V, Struys MM, Hans PC, Lamy ML and Joris JL: Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation. Br J Anaesth. 105:471–479. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Ahn E, Kang H, Choi GJ, Park YH, Yang SY, Kim BG and Choi SW: Intravenous lidocaine for effective pain relief after a laparoscopic colectomy: A prospective, randomized, double-blind, placebo-controlled study. Int Surg. 100:394–401. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Koppert W, Weigand M, Neumann F, Sittl R, Schuettler J, Schmelz M and Hering W: Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth Analg. 98:1050–1055. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Zhang J, Zhang H, Zhao L, Gu J, Feng Y and An H: Population pharmacokinetic modeling of flurbiprofen, the active metabolite of flurbiprofen axetil, in Chinese patients with postoperative pain. J Pain Res. 11:3061–3070. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Fujii Y and Itakura M: Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: A prospective, randomized, double-blind, parallel-group, placebo-controlled study. Clin Ther. 30:280–286. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Kuo CP, Jao SW, Chen KM, Wong CS, Yeh CC, Sheen MJ and Wu CT: Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth. 97:640–646. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Myles PS, Hunt JO, Fletcher H, Solly R, Woodward D and Kelly S: Relation between quality of recovery in hospital and quality of life at 3 months after cardiac surgery. Anesthesiology. 95:862–867. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Murphy GS, Szokol JW, Greenberg SB, Avram MJ, Vender JS, Nisman M and Vaughn J: Preoperative dexamethasone enhances quality of recovery after laparoscopic cholecystectomy: Effect on in-hospital and postdischarge recovery outcomes. Anesthesiology. 114:882–890. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Poitras S, Beaule PE and Dervin GF: Validity of a short-term quality of life questionnaire in patients undergoing joint replacement: The quality of recovery-40. J Arthroplasty. 27:1604–1608. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

June 2019
Volume 17 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wang, T., Liu, H., Sun, J.H., Wang, L., & Zhang, J.Y. (2019). Efficacy of intravenous lidocaine in improving post‑operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery. Experimental and Therapeutic Medicine, 17, 4723-4729. https://doi.org/10.3892/etm.2019.7497
MLA
Wang, T., Liu, H., Sun, J. H., Wang, L., Zhang, J. Y."Efficacy of intravenous lidocaine in improving post‑operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery". Experimental and Therapeutic Medicine 17.6 (2019): 4723-4729.
Chicago
Wang, T., Liu, H., Sun, J. H., Wang, L., Zhang, J. Y."Efficacy of intravenous lidocaine in improving post‑operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4723-4729. https://doi.org/10.3892/etm.2019.7497