Finite element analysis for blood accumulation in intracerebral hemorrhage

  • Authors:
    • Peng Ren
    • Bo‑Chu Wang
    • Ya‑Zhou Wang
    • Hai‑Jian Xia
    • Ting‑Wang Guo
    • Xiao‑Fei Li
  • View Affiliations

  • Published online on: April 10, 2019     https://doi.org/10.3892/etm.2019.7474
  • Pages: 4681-4686
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Biomechanical methods may provide a novel way to understand blood accumulation in intracerebral hemorrhage (ICH). The current study presents the results of a biomechanical analysis of blood accumulation in ICH using a finite element analysis, with an emphasis on the pressure exerted by the mass effect of blood in early ICH. A two‑dimensional finite model of the human brain parenchyma and the human ventricular system was developed and analyzed under two preloading conditions. The material properties of the human parenchyma were derived from previous reports. Ogden's theory was applied to describe the stress‑strain association in soft tissue. The results of the present study indicated that maximal stress was located at the two ends of the hemorrhage cavity, with the majority of stresses distributed on the zone surrounding the bleed. The two load environments demonstrated similar stress distributions. The loads put on the detached edges were not less than the intracranial pressure (ICP) when the stress threshold was reached. The results of the present study suggest that the direction of blood accumulation can be determined by the shape of the initial blood mass. Mechanical factors (blood pressure and ICP) did not serve a definitive role in preventing blood from accumulating in the early stages of ICH. The present study may aid in understanding the effects of mechanical factors in blood accumulation and hemostasis in patients with early ICH.

References

1 

Xi G, Strahle J, Hua Y and Keep RF: Progress in translational research on intracerebral hemorrhage: Is there an end in sight? Prog Neurobiol. 115:45–63. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Wu G, Xi G and Huang F: Spontaneous intracerebral hemorrhage in humans: Hematoma enlargement, clot lysis, and brain edema. Acta Neurochir Suppl. 96:78–80. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Steiner T, Al-Shahi Salman R, Beer R, Christensen H, Cordonnier C, Csiba L, Forsting M, Harnof S, Klijn CJ, Krieger D, et al: European stroke organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage. Int J Stroke. 9:840–855. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kalita J, Misra UK, Vajpeyee A, Phadke RV, Handique A and Salwani V: Brain herniations in patients with intracerebral hemorrhage. Acta Neurol Scand. 119:254–260. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Hiploylee C and Colbourne F: Intracranial pressure measured in freely moving rats for days after intracerebral hemorrhage. Exp Neurol. 255:49–55. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Fung YCB: Elasticity of soft tissues in simple elongation. Am J Physiol. 213:1532–1544. 1967. View Article : Google Scholar : PubMed/NCBI

7 

Zebian B and Critchley G: Spontaneous intracranial haemorrhage. Surgery (Oxford). 30:136–141. 2012. View Article : Google Scholar

8 

Estes MS and McElhane JH: Response of brain tissue to compressive loading. New York ASME. 1970.

9 

Miller K and Chinzei K: Constitutive modelling of brain tissue: Experiment and theory. J Biomech. 30:1115–1121. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Goriely A, Geers MA, Holzapfel GA, Jayamohan J, Jérusalem A, Sivaloganathan S, Squier W, van Dommelen JA, Waters S and Kuhl E: Mechanics of the brain: Perspectives, challenges, and opportunities. Biomech Model Mechanobiol. 14:931–965. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Prevost TP, Balakrishnan A, Suresh S and Socrate S: Biomechanics of brain tissue. Acta Biomater. 7:83–95. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Bilston LE, Liu Z and Phan-Thien N: Large strain behaviour of brain tissue in shear: Some experimental data and differential constitutive model. Biorheology. 38:335–345. 2001.PubMed/NCBI

13 

Bayly PV, Black EE, Pedersen RC, Leister EP and Genin GM: In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury. J Biomech. 39:1086–1095. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Rashid B, Destrade M and Gilchrist MD: Mechanical characterization of brain tissue in compression at dynamic strain rates. J Mech Behav Biomed Mater. 10:23–38. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Franceschini G, Bigoni D, Regitnig P and Holzapfel GA: Brain tissue deforms similarly to filled elastomers and follows consolidation theory. J Mech Phys Solids. 54:2592–2620. 2006. View Article : Google Scholar

16 

Jin X, Zhu F, Mao H, Shen M and Yang KH: A comprehensive experimental study on material properties of human brain tissue. J Biomech. 46:2795–2801. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Linninger AA, Tangen K, Hsu CY and Frim D: Cerebrospinal fluid mechanics and its coupling to cerebrovascular dynamics. Ann Rev Fluid Mech. 48:219–257. 2016. View Article : Google Scholar

18 

Taylor Z and Miller K: Reassessment of brain elasticity for analysis of biomechanisms of hydrocephalus. J Biomech. 37:1263–1269. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Wittek A, Miller K, Kikinis R and Warfield SK: Patient-specific model of brain deformation: Application to medical image registration. J Biomech. 40:919–929. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Ren P, Wang BC, Wang YZ, Hao SL, Guo TW and Li XF: Evaluating tensile damage of brain tissue in intracerebral hemorrhage based on strain energy. Exp Ther Med. 16:4843–4852. 2018.PubMed/NCBI

21 

Marmarou A and Beaumont A: Physiology of the cerebrospinal fluid and intracranial pressure. Youmans neurological surgery. Winn HR: 6th. Springer; Philadelphia, PA: pp. 169–182. 2011, View Article : Google Scholar

22 

Maset AL, Marmarou A, Ward JD, Choi S, Lutz HA, Brooks D, Moulton RJ, DeSalles A, Muizelaar JP, Turner H, et al: Pressure-volume index in head-injury. J Neurosurg. 67:832–840. 1987. View Article : Google Scholar : PubMed/NCBI

23 

Tsai MS, Chou YL, Chang GL and Shen CL: The effect of magnitudes and duration of pressure on cerebral cortex in a rat model. J Clin Neurosci. 8:157–163. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Agar A, Li S, Agarwal N, Coroneo MT and Hill MA: Retinal ganglion cell line apoptosis induced by hydrostatic pressure. Brain Res. 1086:191–200. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Tök L, Nazıroğlu M, Uğuz AC and Tök O: Elevated hydrostatic pressures induce apoptosis and oxidative stress through mitochondrial membrane depolarization in PC12 neuronal cells: A cell culture model of glaucoma. J Recept Signal Transduct Res. 34:410–416. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Xi G, Keep RF and Hoff JT: Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 5:53–63. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Gore RW: Pressures in cat mesenteric arterioles and capillaries during changes in systemic arterial blood pressure. Circ Res. 34:581–591. 1974. View Article : Google Scholar : PubMed/NCBI

28 

Lipowsky HH: Microvascular rheology and hemodynamics. Microcirculation. 12:5–15. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Boas DA, Jones SR, Devor A, Huppert TJ and Dale AM: A vascular anatomical network model of the spatio-temporal response to brain activation. Neuroimage. 40:1116–1129. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

June 2019
Volume 17 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Ren, P., Wang, B., Wang, Y., Xia, H., Guo, T., & Li, X. (2019). Finite element analysis for blood accumulation in intracerebral hemorrhage. Experimental and Therapeutic Medicine, 17, 4681-4686. https://doi.org/10.3892/etm.2019.7474
MLA
Ren, P., Wang, B., Wang, Y., Xia, H., Guo, T., Li, X."Finite element analysis for blood accumulation in intracerebral hemorrhage". Experimental and Therapeutic Medicine 17.6 (2019): 4681-4686.
Chicago
Ren, P., Wang, B., Wang, Y., Xia, H., Guo, T., Li, X."Finite element analysis for blood accumulation in intracerebral hemorrhage". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4681-4686. https://doi.org/10.3892/etm.2019.7474