Open Access

Multi‑walled carbon nanotube‑based systems for improving the controlled release of insoluble drug dipyridamole

  • Authors:
    • Wenquan Zhu
    • Haitao Huang
    • Yan Dong
    • Cuiyan Han
    • Xiaoyu Sui
    • Baiyu Jian
  • View Affiliations

  • Published online on: April 19, 2019     https://doi.org/10.3892/etm.2019.7510
  • Pages: 4610-4616
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Abstract

Applicability of multi‑walled carbon nanotubes (MWCNTs) in loading dipyridamole (DDM), a poorly soluble drug, was evaluated. Additionally, the effect of drug‑loading efficiency on the release behavior of the MWCNT‑DDM system was also investigated. DDM as a model drug was incorporated into MWCNTs with different drug‑loading rates (10, 25 and 50%) using the solvent deposition method. The MWCNT‑DDM system was successfully established and characterized using common solid‑state characterization methods. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption analysis and Fourier transform‑infrared (FT‑IR) spectroscopy were carried out to observe the progress of drug loading. X‑ray diffraction (XRD) and differential scanning calorimetry (DSC) were used to systematically assess the crystalline state of the DDM after being loaded into the MWCNTs. Improvements in dissolution rate were evaluated by the dissolution test. The results revealed that with the increase of drug loading, the form of DDM in the MWCNTs changed from amorphous to crystalline state. Also, the release rate of DDM decreased upon increasing the drug‑loading rate of carriers. In conclusion, MWCNTs are proven to be promising carriers for loading DDM.

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June 2019
Volume 17 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Zhu, W., Huang, H., Dong, Y., Han, C., Sui, X., & Jian, B. (2019). Multi‑walled carbon nanotube‑based systems for improving the controlled release of insoluble drug dipyridamole . Experimental and Therapeutic Medicine, 17, 4610-4616. https://doi.org/10.3892/etm.2019.7510
MLA
Zhu, W., Huang, H., Dong, Y., Han, C., Sui, X., Jian, B."Multi‑walled carbon nanotube‑based systems for improving the controlled release of insoluble drug dipyridamole ". Experimental and Therapeutic Medicine 17.6 (2019): 4610-4616.
Chicago
Zhu, W., Huang, H., Dong, Y., Han, C., Sui, X., Jian, B."Multi‑walled carbon nanotube‑based systems for improving the controlled release of insoluble drug dipyridamole ". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4610-4616. https://doi.org/10.3892/etm.2019.7510