Open Access

Evaluation of ultrasonography on carotid arteries and left ventricular function in patients with subclinical atherosclerosis

  • Authors:
    • Tao Zhang
    • Haiwei Yin
    • Hanwen Xue
  • View Affiliations

  • Published online on: April 22, 2019     https://doi.org/10.3892/etm.2019.7517
  • Pages: 4465-4470
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ultrasonography in the evaluation and diagnosis of carotid arteries and left ventricular function in patients with subclinical atherosclerosis (SA) was explored. In total, 152 patients with no obvious clinical symptoms of atherosclerosis confirmed by carotid ultrasonography in Tengzhou Central People's Hospital from September 2015 to March 2016 were enrolled as the experimental group, and further 45 patients with normal physical examination at the same time were collected as the control group. Patients in the experimental group were divided into three groups according to Framingham risk assessment: low, middle and high risk. The carotid arteries and left ventricular function of all patients were detected by Doppler ultrasound. There were differences in the systolic pressure, TG and TC between the control group and the experimental group (P<0.05). The expression levels of β, cIMT, Ep and PWVβ increased with the risk degree in the low, middle and high risk groups (P<0.05). The expression levels of LVEDV, LVESV, and LVEF in the experimental group were significantly decreased compared with those in the control group (P<0.05), while the expression levels of LAV, E/e, GLS and GCS were significantly increased compared with those in the control group (P<0.05). There was a difference of left ventricular function parameters in the low, medium and high risk groups (P<0.05). The expression levels of LVEDV, LVESV, LAV and E/e increased with the risk degree in the low, middle and high risk groups (P<0.05). The detection rate of plaque was lower in the low risk group than those in the middle and high risk group (P<0.05). By observing the parameters of carotid arteries and left ventricular function, it was found that ultrasonography has important clinical value in the early diagnosis of SA, and can be promoted in clinic.

References

1 

Dal-Ré R: Early phase drugs and biologicals clinical trials on worldwide leading causes of death: A descriptive analysis. Eur J Clin Pharmacol. 67:563–571. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Du H, Li L, Bennett D, Guo Y, Key TJ, Bian Z, Sherliker P, Gao H, Chen Y, Yang L, et al China Kadoorie Biobank Study, : Fresh fruit consumption and major cardiovascular disease in China. N Engl J Med. 374:1332–1343. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Al-Sharea A, Murphy AJ, Huggins LA, Hu Y, Goldberg IJ and Nagareddy PR: SGLT2 inhibition reduces atherosclerosis by enhancing lipoprotein clearance in Ldlr−/− type 1 diabetic mice. Atherosclerosis. 271:166–176. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Ambrosino P, Lupoli R, Di Minno A, Tasso M, Peluso R and Di Minno MN: Subclinical atherosclerosis in patients with rheumatoid arthritis. A meta-analysis of literature studies. Thromb Haemost. 113:916–930. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, et al American Heart Association Statistics Committee and Stroke Statistics Subcommittee, : Heart Disease and Stroke Statistics-2017 Update: A report from the American Heart Association. Circulation. 135:e146–e603. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Weber LA, Cheezum MK, Reese JM, Lane AB, Haley RD, Lutz MW and Villines TC: Cardiovascular imaging for the primary prevention of atherosclerotic cardiovascular disease events. Curr Cardiovasc Imaging Rep. 8:362015. View Article : Google Scholar : PubMed/NCBI

7 

de Almeida-Pititto B, Ribeiro-Filho FF, Bittencourt MS, Lotufo PA, Bensenor I and Ferreira SR: Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Diabetol Metab Syndr. 8:192016. View Article : Google Scholar : PubMed/NCBI

8 

Huang R, Abdelmoneim SS, Ball CA, Nhola LF, Farrell AM, Feinstein S and Mulvagh SL: Detection of carotid atherosclerotic plaque neovascularization using contrast enhanced ultrasound: A systematic review and meta-analysis of diagnostic accuracy studies. J Am Soc Echocardiogr. 29:491–502. 2016. View Article : Google Scholar : PubMed/NCBI

9 

ten Kate GL, van Dijk AC, van den Oord SC, Hussain B, Verhagen HJ, Sijbrands EJ, van der Steen AF, van der Lugt A and Schinkel AF: Usefulness of contrast-enhanced ultrasound for detection of carotid plaque ulceration in patients with symptomatic carotid atherosclerosis. Am J Cardiol. 112:292–298. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, et al: Association of HDL cholesterol efflux capacity with incident coronary heart disease events: A prospective case-control study. Lancet Diabetes Endocrinol. 3:507–513. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Wilmot KA, O'Flaherty M, Capewell S, Ford ES and Vaccarino V: Coronary heart disease mortality declines in the United States from 1979 through 2011: Evidence for stagnation in young adults, especially women. Circulation. 132:997–1002. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Poredoš P and Ježovnik MK: Markers of preclinical atherosclerosis and their clinical relevance. Vasa. 44:247–256. 2015. View Article : Google Scholar : PubMed/NCBI

13 

McClelland RL, Jorgensen NW, Budoff M, Blaha MJ, Post WS, Kronmal RA, Bild DE, Shea S, Liu K, Watson KE, et al: 10-Year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors: Derivation in the MESA (Multi-Ethnic Study of Atherosclerosis) with validation in the HNR (Heinz Nixdorf Recall) Study and the DHS (Dallas Heart Study). J Am Coll Cardiol. 66:1643–1653. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Matsushita K, Sang Y, Ballew SH, Shlipak M, Katz R, Rosas SE, Peralta CA, Woodward M, Kramer HJ, Jacobs DR, et al: Subclinical atherosclerosis measures for cardiovascular prediction in CKD. J Am Soc Nephrol. 26:439–447. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Gourgari E, Dabelea D and Rother K: Modifiable risk factors for cardiovascular disease in children with type 1 diabetes: can early intervention prevent future cardiovascular events? Curr Diab Rep. 17:1342017. View Article : Google Scholar : PubMed/NCBI

16 

Sansone R, Rodriguez-Mateos A, Heuel J, Falk D, Schuler D, Wagstaff R, Kuhnle GG, Spencer JP, Schroeter H, Merx MW, et al Flaviola Consortium, European Union 7th Framework Program, : Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: A randomised, controlled, double-masked trial: the Flaviola Health Study. Br J Nutr. 114:1246–1255. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Rosengarten B and Kaps M: A simultaneous EEG and transcranial Doppler technique to investigate the neurovascular coupling in the human visual cortex. Cerebrovasc Dis. 29:211–216. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Yang S, Wang DZ, Zhang HX, He W and Chen BX: Echo-tracking technology assessment of carotid artery stiffness in patients with coronary slow flow. Ultrasound Med Biol. 41:72–76. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhang P, Guo R, Li Z, Xiao D, Ma L, Huang P and Wang C: Effect of smoking on common carotid artery wall elasticity evaluated by echo tracking technique. Ultrasound Med Biol. 40:643–649. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Lee SJ and Park SH: Arterial ageing. Korean Circ J. 43:73–79. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Zhang P, Guo R, Xiao D, Chu S, Gong L, Zhang C, Jing B and Li M: Influence of smoking cessation on carotid artery wall elasticity evaluated by echo-tracking. J Clin Ultrasound. 40:352–356. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P and Weissleder R: Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 114:1504–1511. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Ling Y, Wan Q, Chen Q and Zhu W: Assessment of subtle cardiac dysfunction in patients with frequent premature ventricular complexes by real-time three-dimensional speckle tracking echocardiography. Clin Cardiol. 40:554–558. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Huang X, Kang X, Xue J, Kang C, Lv H and Li Z: Evaluation of carotid artery elasticity changes in patients with cerebral small vessel disease. Int J Clin Exp Med. 8:18825–18830. 2015.PubMed/NCBI

25 

Agoşton-Coldea L, Mocan T and Bobar C: Arterial stiffness and left ventricular diastolic function in the patients with hypertension. Rom J Intern Med. 46:313–321. 2008.PubMed/NCBI

Related Articles

Journal Cover

June 2019
Volume 17 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhang, T., Yin, H., & Xue, H. (2019). Evaluation of ultrasonography on carotid arteries and left ventricular function in patients with subclinical atherosclerosis. Experimental and Therapeutic Medicine, 17, 4465-4470. https://doi.org/10.3892/etm.2019.7517
MLA
Zhang, T., Yin, H., Xue, H."Evaluation of ultrasonography on carotid arteries and left ventricular function in patients with subclinical atherosclerosis". Experimental and Therapeutic Medicine 17.6 (2019): 4465-4470.
Chicago
Zhang, T., Yin, H., Xue, H."Evaluation of ultrasonography on carotid arteries and left ventricular function in patients with subclinical atherosclerosis". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4465-4470. https://doi.org/10.3892/etm.2019.7517