Open Access

Association of Helicobacter pylori infection with metabolic syndrome in aged Chinese females

  • Authors:
    • Yingying Yu
    • Jianting Cai
    • Zhenya Song
    • Jinghua Wang
    • Lingyan Wu
  • View Affiliations

  • Published online on: April 19, 2019     https://doi.org/10.3892/etm.2019.7509
  • Pages: 4403-4408
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) determined in different cohorts from different countries is currently inconclusive. In the majority of previous studies, H. pylori infection was diagnosed based on the presence of H. pylori IgG antibody in the serum. However, to the best of our knowledge, only few studies have investigated the association between H. pylori infection and MetS using the urea breath test (UBT) as a diagnostic tool. The present study was performed with the aim of providing a detailed analysis of the association between H. pylori infection, as diagnosed by the UBT method, and MetS in a large community from Zhejiang province in eastern China. The results indicated that H. pylori infection increases the risk of MetS in the aged female population.

References

1 

Samson SL and Garber AJ: Metabolic syndrome. Endocrinol Metab Clin North Am. 43:1–23. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Giudice A, Crispo A, Massimiliano G, D'Arena G, Tecce MF, Grimaldi M, Amore A, Esposito E and Montella M: Metabolic syndrome, insulin resistance, circadian disruption, antioxidants and pancreatic carcinoma: An overview. J Gastrointestin Liver Dis. 23:73–77. 2014.PubMed/NCBI

3 

Hoffman EL, VonWald T and Hansen K: The metabolic syndrome. S D Med. 9:24–28. 2015.

4 

Festa A, D'Agostino R Jr, Howard G, Mykkänen L, Tracy RP and Haffner SM: Chronic subclinical inflammation as part of the insulin resistance syndrome: The insulin resistance atherosclerosis study (IRAS). Circulation. 102:42–47. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Suerbaum S and Michetti P: Helicobacter pylori infection. N Engl J Med. 347:1175–1186. 2002. View Article : Google Scholar : PubMed/NCBI

6 

McColl KE: Clinical practice. Helicobacter pylori infection. N Engl J Med. 362:1597–1604. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Qadri Q, Rasool R, Gulzar GM, Naqash S and Shah ZA: H. pylori infection, inflammation and gastric cancer. J Gastrointest Cancer. 45:126–132. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Atherton JC: The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annu Rev Pathol. 1:63–96. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Lee YC, Chen TH, Chiu HM, Shun CT, Chiang H, Liu TY, Wu MS and Lin JT: The benefit of mass eradication of Helicobacter pylori infection: A community-based study of gastric cancer prevention. Gut. 62:676–682. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Malfertheiner P, Megraud F, O'Morain CA, Gisbert JP, Kuipers EJ, Axon AT, Bazzoli F, Gasbarrini A, Atherton J, Graham DY, et al: Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 66:6–30. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Oshima T, Ozono R, Yano Y, Oishi Y, Teragawa H, Higashi Y, Yoshizumi M and Kambe M: Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. J Am Coll Cardiol. 45:1219–1222. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Franceschi F, Annalisa T, Teresa DR, Giovanna D, Ianiro G, Franco S, Viviana G, Valentina T, Riccardo LL and Antonio G: Role of Helicobacter pylori infection on nutrition and metabolism. World J Gastroenterol. 20:12809–12817. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Kyburz A and Muller A: Helicobacter pylori and extragastric diseases. Curr Top Microbiol Immunol. 400:325–347. 2017.PubMed/NCBI

14 

Goni E and Franceschi F: Helicobacter pylori and extragastric diseases. Helicobacter. 21 (Suppl 1):S45–S48. 2016. View Article : Google Scholar

15 

Albaker WI: Helicobacter pylori infection and its relationship to metabolic syndrome: Is it a myth or fact? Saudi J Gastroenterol. 17:165–169. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Chen LW, Chien CY, Yang KJ, Kuo SF, Chen CH and Chien RN: Helicobacter pylori infection increases insulin resistance and metabolic syndrome in residents younger than 50 years old: A community-based study. PLoS One. 10:e01286712015. View Article : Google Scholar : PubMed/NCBI

17 

Chen TP, Hung HF, Chen MK, Lai HH, Hsu WF, Huang KC and Yang KC: Helicobacter pylori infection is positively associated with metabolic syndrome in taiwanese adults: A cross-sectional study. Helicobacter. 20:184–191. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Işıktaş Sayılar E, Çelik B and Dumlu Ş: Relationship between Helicobacter pylori infection and metabolic syndrome. Turk J Gastroenterol. 26:468–473. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Koklu H, Koklu S and Cinar H: Helicobacter pylori and metabolic syndrome. Turk J Gastroenterol. 27:2012016. View Article : Google Scholar : PubMed/NCBI

20 

Vafaeimanesh J, Bagherzadeh M, Mirzaei A, Parham M, Norouzinia M and Vafaee R: Effect of Helicobacter pylori on metabolic syndrome parameters in diabetic patients. Gastroenterol Hepatol Bed Bench. 9 (Suppl 1):S36–S41. 2016.PubMed/NCBI

21 

Upala S, Jaruvongvanich V, Riangwiwat T, Jaruvongvanich S and Sanguankeo A: Association between Helicobacter pylori infection and metabolic syndrome: A systematic review and meta-analysis. J Dig Dis. 17:433–440. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Polyzos SA and Kountouras J: Novel advances in the association between helicobacter pylori infection, metabolic syndrome, and related morbidity. Helicobacter. 20:405–409. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kayar Y, Pamukçu Ö, Eroğlu H, Kalkan Erol K, Ilhan A and Kocaman O: Relationship between Helicobacter pylori infections in diabetic patients and inflammations, metabolic syndrome, and complications. Int J Chronic Dis. 2015:2901282015.PubMed/NCBI

24 

Lu LJ, Hao NB, Liu JJ, Li X and Wang RL: Correlation between Helicobacter pylori infection and metabolic abnormality in general population: A cross-sectional study. Gastroenterol Res Pract. 2018:74108012018. View Article : Google Scholar : PubMed/NCBI

25 

Yang W and Xuan C: Influence of Helicobacter pylori infection on metabolic syndrome in old chinese people. Gastroenterol Res Pract. 2016:69512642016. View Article : Google Scholar : PubMed/NCBI

26 

Ando T, Ishikawa T, Takagi T, Imamoto E, Kishimoto E, Okajima A, Uchiyama K, Handa O, Yagi N, Kokura S, et al: Impact of Helicobacter pylori eradication on circulating adiponectin in humans. Helicobacter. 18:158–164. 2013. View Article : Google Scholar : PubMed/NCBI

27 

de Luis DA, Garcia Avello A, Lasuncion MA, Aller R, Martin de Argila C, Boixeda de Miquel D and de la Calle H: Improvement in lipid and haemostasis patterns after Helicobacter pylori infection eradication in type 1 diabetic patients. Clin Nutr. 18:227–231. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Gen R, Demir M and Ataseven H: Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation. South Med J. 103:190–196. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Devaraj S, Rosenson RS and Jialal I: Metabolic syndrome: An appraisal of the pro-inflammatory and procoagulant status. Endocrinol Metab Clin North Am. 33:431–453. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Gillum RF: Infection with Helicobacter pylori, coronary heart disease, cardiovascular risk factors, and systemic inflammation: The third national health and nutrition examination survey. J Natl Med Assoc. 96:1470–1476. 2004.PubMed/NCBI

31 

Naja F, Nasreddine L, Hwalla N, Moghames P, Shoaib H, Fatfat M, Sibai A and Gali-Muhtasib H: Association of H. pylori infection with insulin resistance and metabolic syndrome among lebanese adults. Helicobacter. 17:444–451. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Tamura T, Morita E, Kawai S, Sasakabe T, Sugimoto Y, Fukuda N, Suma S, Nakagawa H, Okada R, Hishida A, et al: No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: A cross-sectional study. Springerplus. 4:6022015. View Article : Google Scholar : PubMed/NCBI

33 

Miernyk KM, Bruden DL, Bruce MG, McMahon BJ, Hennessy TW, Peters HV, Hurlburt DA, Sacco F and Parkinson AJ: Dynamics of Helicobacter pylori-specific immunoglobulin G for 2 years after successful eradication of Helicobacter pylori infection in an American Indian and Alaska native population. Clin Vaccine Immunol. 14:85–86. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Ferwana M, Abdulmajeed I, Alhajiahmed A, Madani W, Firwana B, Hasan R, Altayar O, Limburg PJ, Murad MH and Knawy B: Accuracy of urea breath test in Helicobacter pylori infection: Meta-analysis. World J Gastroenterol. 21:1305–1314. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Alberti KG, Zimmet P and Shaw J; IDF Epidemiology Task Force Consensus Group, : The metabolic syndrome-a new worldwide definition. Lancet. 366:1059–1062. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Gayoso-Diz P, Otero-González A, Rodriguez-Alvarez MX, Gude F, García F, De Francisco A and Quintela AG: Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: Effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord. 13:472013. View Article : Google Scholar : PubMed/NCBI

37 

Shin DW, Kwon HT, Kang JM, Park JH, Choi HC, Park MS, Park MS, Park SM, Son KY and Cho B: Association between metabolic syndrome and Helicobacter pylori infection diagnosed by histologic status and serological status. J Clin Gastroenterol. 46:840–845. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Refaeli R, Chodick G, Haj S, Goren S, Shalev V and Muhsen K: Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: A large cross-sectional study. Sci Rep. 8:40882018. View Article : Google Scholar : PubMed/NCBI

39 

Figueroa-Vega N, Moreno-Frías C and Malacara JM: Alterations in adhesion molecules, pro-inflammatory cytokines and cell-derived microparticles contribute to intima-media thickness and symptoms in postmenopausal women. PLoS One. 10:e01209902015. View Article : Google Scholar : PubMed/NCBI

40 

Taleb-Belkadi O, Chaib H, Zemour L, Fatah A, Chafi B and Mekki K: Lipid profile, inflammation, and oxidative status in peri- and postmenopausal women. Gynecol Endocrinol. 32:982–985. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

June 2019
Volume 17 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Yu, Y., Cai, J., Song, Z., Wang, J., & Wu, L. (2019). Association of Helicobacter pylori infection with metabolic syndrome in aged Chinese females. Experimental and Therapeutic Medicine, 17, 4403-4408. https://doi.org/10.3892/etm.2019.7509
MLA
Yu, Y., Cai, J., Song, Z., Wang, J., Wu, L."Association of Helicobacter pylori infection with metabolic syndrome in aged Chinese females". Experimental and Therapeutic Medicine 17.6 (2019): 4403-4408.
Chicago
Yu, Y., Cai, J., Song, Z., Wang, J., Wu, L."Association of Helicobacter pylori infection with metabolic syndrome in aged Chinese females". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4403-4408. https://doi.org/10.3892/etm.2019.7509