Open Access

Roles of Eph/ephrin bidirectional signaling in central nervous system injury and recovery (Review)

  • Authors:
    • Jin‑Shan Yang
    • Hui‑Xing Wei
    • Ping‑Ping Chen
    • Gang Wu
  • View Affiliations

  • Published online on: January 4, 2018     https://doi.org/10.3892/etm.2018.5702
  • Pages:2219-2227
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multiple cellular components are involved in the complex pathological process following central nervous system (CNS) injury, including neurons, glial cells and endothelial cells. Previous studies and neurotherapeutic clinical trials have assessed the molecular mechanisms that underlie neuronal cell death following CNS injury. However, this approach has largely failed to reduce CNS damage or improve the functional recovery of patients. Erythropoietin‑producing human hepatocellular (Eph) receptors and ephrin ligands have attracted considerable attention since their discovery, due to their extensive distribution and unique bidirectional signaling between astrocytes and neurons. Previous studies have investigated the roles of Eph/ephrin bidirectional signaling in the developing central nervous system. It was determined that Eph/ephrin bidirectional signaling is expressed in various CNS regions and cell types, and that it serves diverse roles in the adult CNS. In the present review, the roles of Eph/ephrin bidirectional signaling in CNS injuries are assessed.

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March 2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

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APA
Yang, J., Wei, H., Chen, P., & Wu, G. (2018). Roles of Eph/ephrin bidirectional signaling in central nervous system injury and recovery (Review). Experimental and Therapeutic Medicine, 15, 2219-2227. https://doi.org/10.3892/etm.2018.5702
MLA
Yang, J., Wei, H., Chen, P., Wu, G."Roles of Eph/ephrin bidirectional signaling in central nervous system injury and recovery (Review)". Experimental and Therapeutic Medicine 15.3 (2018): 2219-2227.
Chicago
Yang, J., Wei, H., Chen, P., Wu, G."Roles of Eph/ephrin bidirectional signaling in central nervous system injury and recovery (Review)". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2219-2227. https://doi.org/10.3892/etm.2018.5702