Abnormally expressed microRNA as auxiliary biomarkers for nasopharyngeal carcinoma: A meta‑analysis

  • Authors:
    • Zhenzhou Xiao
    • Wei Peng
    • Xusheng Zhou
    • Xiaoli Luo
    • Yan Chen
    • Zhaolei Cui
  • View Affiliations

  • Published online on: November 29, 2017     https://doi.org/10.3892/br.2017.1026
  • Pages:99-105
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Abstract

Aberrant expression of microRNA (miRNA) has been highlighted as a helpful indicator to aid in nasopharyngeal carcinoma (NPC) diagnosis. The present meta‑analysis aimed to validate the efficacy of miRNA as potential biomarkers for NPC detection. Publication searches were conducted on the online PubMed and EMBASE databases from inception to June 2016. A bivariate meta‑analysis was performed to generate the diagnostic parameters based on Meta‑Disc 1.4 and Stata 12.0 programs. Sensitivity analysis and meta‑regression tests were applied to trace heterogeneity sources among eligible studies. A total of six studies comprising 528 patients with NPC and 252 matched controls were enrolled. Results from the present meta‑analysis demonstrated that miRNA testing achieved a pooled sensitivity of 0.78 [95% confidence interval (CI), 0.70‑0.84] and specificity of 0.79 (95% CI, 0.73‑0.84) in confirming NPC, corresponding to an area under the curve (AUC) value of 0.85. Additionally, the pooled diagnostic odds ratio was estimated to be 9.01 (95% CI, 5.62‑14.44), along with a positive likelihood ratio of 2.81 (95% CI, 2.19‑3.61) and negative likelihood ratio of 0.35 (95% CI, 0.28‑0.44). Additionally, the stratified analyses revealed that paralleled testing of miRNA sustained a pooled accuracy superior compared with that of single miRNA testing (sensitivity, 0.88 vs. 0.70; specificity, 0.85 vs. 0.69; AUC, 0.95 vs. 0.75). Testing of miRNA harbors a moderate diagnostic efficacy and is acceptable as an auxiliary biomarker for NPC diagnosis.

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January 2018
Volume 8 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
APA
Xiao, Z., Peng, W., Zhou, X., Luo, X., Chen, Y., & Cui, Z. (2018). Abnormally expressed microRNA as auxiliary biomarkers for nasopharyngeal carcinoma: A meta‑analysis. Biomedical Reports, 8, 99-105. https://doi.org/10.3892/br.2017.1026
MLA
Xiao, Z., Peng, W., Zhou, X., Luo, X., Chen, Y., Cui, Z."Abnormally expressed microRNA as auxiliary biomarkers for nasopharyngeal carcinoma: A meta‑analysis". Biomedical Reports 8.1 (2018): 99-105.
Chicago
Xiao, Z., Peng, W., Zhou, X., Luo, X., Chen, Y., Cui, Z."Abnormally expressed microRNA as auxiliary biomarkers for nasopharyngeal carcinoma: A meta‑analysis". Biomedical Reports 8, no. 1 (2018): 99-105. https://doi.org/10.3892/br.2017.1026