Cardiovascular characteristics of chronic fatigue syndrome

  • Authors:
    • Sara Bozzini
    • Andrea Albergati
    • Enrica Capelli
    • Lorenzo Lorusso
    • Carmine Gazzaruso
    • Gabriele Pelissero
    • Colomba Falcone
  • View Affiliations

  • Published online on: November 28, 2017     https://doi.org/10.3892/br.2017.1024
  • Pages: 26-30
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Patients with chronic fatigue syndrome (CFS) commonly exhibit orthostatic intolerance. Abnormal sympathetic predominance in the autonomic cardiovascular response to gravitational stimuli was previously described in numerous studies. The aim of the current study was to describe cardiological and clinical characteristics of Italian patients with CFS. All of the patients were of Caucasian ethnicity and had been referred to our center, the Cardiology Department of the University Hospital of Pavia (Pavia, Italy) with suspected CFS. A total of 44 patients with suspected CFS were included in the present study and the diagnosis was confirmed in 19 patients according to recent clinical guidelines. The characteristics at baseline of the population confirm findings from various previous reports regarding the prevalence in females with a female to male ratio of 4:1, the age of onset of the pathology and the presence of previous infection by the Epstein-Barr virus, cytomegalovirus and other human herpesviruses. Despite the current data indicating that the majority of the cardiological parameters investigated are not significantly different in patients with and without CFS, a significant association between the disease and low levels of blood pressure was identified. Other pilot studies revealed a higher prevalence of hypotension and orthostatic intolerance in patients with CFS. Furthermore, many of the CFS symptoms, including fatigue, vertigo, decreased concentration, tremors and nausea, may be explained by hypotension.

References

1 

Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG and Komaroff A; International Chronic Fatigue Syndrome Study Group, : The chronic fatigue syndrome: A comprehensive approach to its definition and study. Ann Intern Med. 121:953–959. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Brurberg KG, Fønhus MS, Larun L, Flottorp S and Malterud K: Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): A systematic review. BMJ Open. 4:e0039732014. View Article : Google Scholar : PubMed/NCBI

3 

Fischer DB, William AH, Strauss AC, Unger ER, Jason L, Marshall GD Jr and Dimitrakoff JD: Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers. Fatigue. 2:93–109. 2014.PubMed/NCBI

4 

Wyller VB, Saul JP, Walløe L and Thaulow E: Sympathetic cardiovascular control during orthostatic stress and isometric exercise in adolescent chronic fatigue syndrome. Eur J Appl Physiol. 102:623–632. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H and Calders P: Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: A systematic review. Semin Arthritis Rheum. 43:279–287. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Miwa K: Cardiac dysfunction and orthostatic intolerance in patients with myalgic encephalomyelitis and a small left ventricle. Heart Vessels. 30:484–489. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Wyller VB, Barbieri R and Saul JP: Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. Eur J Appl Physiol. 111:497–507. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Falcone C, de Servi S, Poma E, Campana C, Sciré A, Montemartini C and Specchia G: Clinical significance of exercise-induced silent myocardial ischemia in patients with coronary artery disease. J Am Coll Cardiol. 9:295–299. 1987. View Article : Google Scholar : PubMed/NCBI

9 

Turnbull N, Shaw EJ, Baker R, Dunsdon S, Costin N, Britton G, et al: Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy): diagnosis and management of chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy) in adults and children. Royal College of General Practitioners, London. 2007.

10 

Reyes M, Gary HE Jr, Dobbins JG, Randall B, Steele L, Fukuda K, Holmes GP, Connell DG, Mawle AC, Schmid DS, et al: Surveillance for chronic fatigue syndrome - four U.S. cities, September 1989 through August 1993. MMWR CDC Surveill Summ. 46:1–13. 1997.PubMed/NCBI

11 

Bansal AS, Bradley AS, Bishop KN, Kiani-Alikhan S and Ford B: Chronic fatigue syndrome, the immune system and viral infection. Brain Behav Immun. 26:24–31. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Underhill RA: Myalgic encephalomyelitis, chronic fatigue syndrome: An infectious disease. Med Hypotheses. 85:765–773. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Jason LA, Richman JA, Rademaker AW, Jordan KM, Plioplys AV, Taylor RR, McCready W, Huang CF and Plioplys S: A community-based study of chronic fatigue syndrome. Arch Intern Med. 159:2129–2137. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Lloyd AR, Hickie I, Boughton CR, Spencer O and Wakefield D: Prevalence of chronic fatigue syndrome in an Australian population. Med J Aust. 153:522–528. 1990.PubMed/NCBI

15 

Lawrie SM and Pelosi AJ: Chronic fatigue syndrome in the community. Prevalence and associations. Br J Psychiatry. 166:793–797. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Johnston SC, Staines DR and Marshall-Gradisnik SM: Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients. Clin Epidemiol. 8:97–107. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Glaser R and Kiecolt-Glaser JK: Stress-associated immune modulation: Relevance to viral infections and chronic fatigue syndrome. Am J Med. 105(3A): 35S–42S. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Bozzini S, Boiocchi C, Carlo-Stella N, Ricevuti G and Cuccia M: The possible underworld of Chronic Fatigue Syndrome: From neurotransmitters polymorphisms to disease. J Neurol Res. 2:16–24. 2012.

19 

Pasi A, Bozzini S, Carlo-Stella N, Martinetti M, Bombardieri S, De Silvestri A, Salvaneschi L and Cuccia M: Excess of activating killer cell immunoglobulin like receptors and lack of HLA-Bw4 ligands: A two edged weapon in chronic fatigue syndrome. Mol Med Rep. 4:535–540. 2011.PubMed/NCBI

20 

Carlo-Stella N, Bozzini S, De Silvestri A, Sbarsi I, Pizzochero C, Lorusso L, Martinetti M and Cuccia M: Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome. Int J Immunopathol Pharmacol. 22:745–754. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Ortega-Hernandez OD, Cuccia M, Bozzini S, Bassi N, Moscavitch S, Diaz-Gallo LM, Blank M, Agmon-Levin N and Shoenfeld Y: Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: Are they associated with age at onset and specific symptoms? Ann N Y Acad Sci. 1173:589–599. 2009. View Article : Google Scholar : PubMed/NCBI

22 

van't Leven M, Zielhuis GA, van der Meer JW, Verbeek AL and Bleijenberg G: Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Public Health. 20:251–257. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Flores S, Brown A, Adeoye S, Jason LA and Evans M: Examining the impact of obesity on individuals with chronic fatigue syndrome. Workplace Health Saf. 61:299–307. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Wyller VB and Helland IB: Relationship between autonomic cardiovascular control, case definition, clinical symptoms, and functional disability in adolescent chronic fatigue syndrome: An exploratory study. Biopsychosoc Med. 7:52013. View Article : Google Scholar : PubMed/NCBI

25 

Newton JL, Sheth A, Shin J, Pairman J, Wilton K, Burt JA and Jones DE: Lower ambulatory blood pressure in chronic fatigue syndrome. Psychosom Med. 71:361–365. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Frith J, Zalewski P, Klawe JJ, Pairman J, Bitner A, Tafil-Klawe M and Newton JL: Impaired blood pressure variability in chronic fatigue syndrome - a potential biomarker. QJM. 105:831–838. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

January 2018
Volume 8 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Bozzini, S., Albergati, A., Capelli, E., Lorusso, L., Gazzaruso, C., Pelissero, G., & Falcone, C. (2018). Cardiovascular characteristics of chronic fatigue syndrome. Biomedical Reports, 8, 26-30. https://doi.org/10.3892/br.2017.1024
MLA
Bozzini, S., Albergati, A., Capelli, E., Lorusso, L., Gazzaruso, C., Pelissero, G., Falcone, C."Cardiovascular characteristics of chronic fatigue syndrome". Biomedical Reports 8.1 (2018): 26-30.
Chicago
Bozzini, S., Albergati, A., Capelli, E., Lorusso, L., Gazzaruso, C., Pelissero, G., Falcone, C."Cardiovascular characteristics of chronic fatigue syndrome". Biomedical Reports 8, no. 1 (2018): 26-30. https://doi.org/10.3892/br.2017.1024