Open Access

Unveiling the gene regulatory landscape in diseases through the identification of DNase I‑hypersensitive sites (Review)

  • Authors:
    • Ying Chen
    • Ailing Chen
  • View Affiliations

  • Published online on: July 31, 2019     https://doi.org/10.3892/br.2019.1233
  • Pages: 87-97
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

DNase I‑hypersensitive sites (DHSs) serve key roles in the regulation of gene transcription as markers of cis‑regulatory elements (CREs). Recent advances in next‑generation sequencing have enabled the genome‑wide location and annotation of DHSs in a variety of cells. Numerous studies have confirmed that DHSs are involved in several processes in cell fate decision and development. DHSs have also been indicated in cancer and inherited diseases as driver distal regulatory elements. Here, the definition of DHSs is reviewed, in addition to high‑throughput methods of DHS identification. Furthermore, the function of DHSs in gene expression is probed. The roles of DHSs in disease occurrence are also reviewed and discussed. Concomitant advances in the identification of essential roles of DHSs will assist in disclosing the underlying molecular mechanisms, supplementing gene transcription and enlarging the molecular basis of DHS‑related bioprocesses, phenotypes, distinct traits and diseases.
View Figures
View References

Related Articles

Journal Cover

September 2019
Volume 11 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Chen, Y., & Chen, Y. (2019). Unveiling the gene regulatory landscape in diseases through the identification of DNase I‑hypersensitive sites (Review). Biomedical Reports, 11, 87-97. https://doi.org/10.3892/br.2019.1233
MLA
Chen, Y., Chen, A."Unveiling the gene regulatory landscape in diseases through the identification of DNase I‑hypersensitive sites (Review)". Biomedical Reports 11.3 (2019): 87-97.
Chicago
Chen, Y., Chen, A."Unveiling the gene regulatory landscape in diseases through the identification of DNase I‑hypersensitive sites (Review)". Biomedical Reports 11, no. 3 (2019): 87-97. https://doi.org/10.3892/br.2019.1233