Open Access

Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway

  • Authors:
    • Bin Hou
    • Wenhan Li
    • Jianhui Li
    • Jia Ma
    • Peng Xia
    • Zhao Liu
    • Qingnuo Zeng
    • Xin Zhang
    • Dongmin Chang
  • View Affiliations

  • Published online on: December 20, 2019     https://doi.org/10.3892/or.2019.7442
  • Pages: 536-548
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the fourth leading cause of cancer‑related mortality worldwide. Thus, identification of the mechanisms involved in the progression of CRC has become a crucial element of facilitating early CRC diagnosis and targeted therapy for patients with advanced CRC. Currently, Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), a type of histidine phosphatase protein, has been confirmed as a tumor suppressor in hepatocellular carcinoma (HCC) and cervical cancer. However, the functions and molecular mechanisms underlying LHPP in CRC remain undefined. The present study revealed that dysregulation of LHPP was frequently observed in CRC tissues and was positively correlated with tumor severity and poor prognosis. Functional experiments demonstrated that overexpression of LHPP impeded CRC cell growth and proliferation in vitro, and was associated with a change in p53 expression and PI3K/AKT activity. In contrast, silencing of LHPP significantly promoted cell growth and proliferation by modulating the PI3K/AKT signaling pathway. Notably, the anti‑CRC effects of LHPP were also observed in nude mouse in vivo experiments. Overall, the data obtained in the present study suggested that LHPP may be exploited as a diagnostic and prognostic candidate for patients with CRC.
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February 2020
Volume 43 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Hou, B., Li, W., Li, J., Ma, J., Xia, P., Liu, Z. ... Chang, D. (2020). Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway. Oncology Reports, 43, 536-548. https://doi.org/10.3892/or.2019.7442
MLA
Hou, B., Li, W., Li, J., Ma, J., Xia, P., Liu, Z., Zeng, Q., Zhang, X., Chang, D."Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway". Oncology Reports 43.2 (2020): 536-548.
Chicago
Hou, B., Li, W., Li, J., Ma, J., Xia, P., Liu, Z., Zeng, Q., Zhang, X., Chang, D."Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway". Oncology Reports 43, no. 2 (2020): 536-548. https://doi.org/10.3892/or.2019.7442