Open Access

MEIS2 promotes cell migration and invasion in colorectal cancer

  • Authors:
    • Ziang Wan
    • Rui Chai
    • Hang Yuan
    • Bingchen Chen
    • Quanjin Dong
    • Boan Zheng
    • Xiaozhou Mou
    • Wensheng Pan
    • Yifeng Tu
    • Qing Yang
    • Shiliang Tu
    • Xinye Hu
  • View Affiliations

  • Published online on: May 15, 2019     https://doi.org/10.3892/or.2019.7161
  • Pages: 213-223
  • Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is one of the most common types of malignancy worldwide. Distant metastasis is a key cause of CRC‑associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mechanisms underlying the regulatory role of MEIS2 in CRC metastasis remain largely unknown. For the first time, the present study demonstrated that MEIS2 serves a role as a promoter of metastasis in CRC. In vivo and in vitro experiments revealed that knockdown of MEIS2 significantly suppressed CRC migration, invasion and the epithelial‑mesenchymal transition. Furthermore, microarray and bioinformatics analyses were performed to investigate the underlying mechanisms of MEIS2 in the regulation of CRC metastasis. Additionally, it was identified that a high expression of MEIS2 was significantly associated with a shorter overall survival time for patients with CRC. The present study demonstrated that MEIS2 may serve as a novel biomarker for CRC.

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July 2019
Volume 42 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
APA
Wan, Z., Chai, R., Yuan, H., Chen, B., Dong, Q., Zheng, B. ... Hu, X. (2019). MEIS2 promotes cell migration and invasion in colorectal cancer. Oncology Reports, 42, 213-223. https://doi.org/10.3892/or.2019.7161
MLA
Wan, Z., Chai, R., Yuan, H., Chen, B., Dong, Q., Zheng, B., Mou, X., Pan, W., Tu, Y., Yang, Q., Tu, S., Hu, X."MEIS2 promotes cell migration and invasion in colorectal cancer". Oncology Reports 42.1 (2019): 213-223.
Chicago
Wan, Z., Chai, R., Yuan, H., Chen, B., Dong, Q., Zheng, B., Mou, X., Pan, W., Tu, Y., Yang, Q., Tu, S., Hu, X."MEIS2 promotes cell migration and invasion in colorectal cancer". Oncology Reports 42, no. 1 (2019): 213-223. https://doi.org/10.3892/or.2019.7161