miR-141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1

  • Authors:
    • Song Xu
    • Jingping Ge
    • Zhengyu Zhang
    • Wenquan Zhou
  • View Affiliations

  • Published online on: January 11, 2018     https://doi.org/10.3892/or.2018.6209
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Abstract

Prostate cancer (PCa) is the most commonly diagnosed male malignancy and the second leading cause of male cancer-related deaths. miR-141 has been demonstrated to be inversely correlated with tumorigenicity. In the present study, we investigated the effect of miR-141 and runt-related transcription factor 1 (RUNX1) on PCa cells. We determined that miR-141 was expressed at a low level and RUNX1 was expressed at a high level in PCa tissues in comparison to that in adjacent normal tissues. Upregulation of miR-141 significantly inhibited cell growth, migration and invasion, and promoted cell apoptosis in PCa cells. Furthermore, miR-141 overexpression suppressed the expression of MMP-2 and MMP-9, and increased the expression of FOXO1 and p21. However, overexpression of RUNX1 could antagonize the effects of miR-141 on PCa cells. Our findings demonstrated that miR-141 could suppress cell growth, migration and invasion and induce cell apoptosis by targeting RUNX1 in PCa cells. Thus, miR-141/RUNX1 play critical roles in the progression of PCa and may be promising targets for the diagnosis and treatment of PCa.

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Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
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APA
Xu, S., Ge, J., Zhang, Z., & Zhou, W. (1899). miR-141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1. Oncology Reports, 0, 0-0. https://doi.org/10.3892/or.2018.6209
MLA
Xu, S., Ge, J., Zhang, Z., Zhou, W."miR-141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1". Oncology Reports 0.0 (1899): 0-0.
Chicago
Xu, S., Ge, J., Zhang, Z., Zhou, W."miR-141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1". Oncology Reports 0, no. 0 (1899): 0-0. https://doi.org/10.3892/or.2018.6209