Open Access

Long non‑coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP

  • Authors:
    • Juan  Xiao
    • Zhaowei  Bing
    • Ge  Xiao
    • Yang  Guan
    • Jian Luan
  • View Affiliations

  • Published online on: January 21, 2020     https://doi.org/10.3892/ol.2020.11323
  • Pages: 2281-2285
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The long non‑coding (lnc)RNA pre‑ribosomal RNA antisense transcripts (PAPAS) can repress ribosomal RNA synthesis, although its role in human disease is currently unknown. The present study aimed to investigate the function of PAPAS in papillary thyroid carcinoma (PTC). PAPAS was downregulated, while the lncRNA HOXA transcript at the distal tip (HOTTIP) was upregulated in patients with PTC. PAPAS and HOTTIP were inversely associated in PTC. PAPAS overexpression led to the downregulation of HOTTIP in PTC cells, while PAPAS expression was not significantly affected by HOTTIP overexpression, suggesting that PAPAS was upstream of HOTTIP. PAPAS expression level decreased, while HOTTIP expression level increased with the increase of clinical staging. PAPAS overexpression led to the inhibition of cell proliferation, while HOTTIP overexpression increased proliferation of PTC cells, and HOTTIP overexpression decreased the effects of PAPAS overexpression. lncRNA PAPAS overexpression may inhibit tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Xiao, J., Bing, Z., Xiao, G., Guan, Y., & Luan, J. (2020). Long non‑coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP. Oncology Letters, 19, 2281-2285. https://doi.org/10.3892/ol.2020.11323
MLA
Xiao, J., Bing, Z., Xiao, G., Guan, Y., Luan, J."Long non‑coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP". Oncology Letters 19.3 (2020): 2281-2285.
Chicago
Xiao, J., Bing, Z., Xiao, G., Guan, Y., Luan, J."Long non‑coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP". Oncology Letters 19, no. 3 (2020): 2281-2285. https://doi.org/10.3892/ol.2020.11323