Open Access

Relationship between platelet‑based models and the prognosis of patients with malignant hepatic tumors

  • Authors:
    • Chen‑Liang Hu
    • Qian‑Cheng Du
    • Zhi‑Xin Wang
    • Ming‑Quan Pang
    • Yan‑Yan Wang
    • Ying‑Yu Li
    • Ying Zhou
    • Hai‑Jiu Wang
    • Hai‑Ning Fan
  • View Affiliations

  • Published online on: January 17, 2020     https://doi.org/10.3892/ol.2020.11317
  • Pages: 2384-2396
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Platelets (PLTs) are involved in tumor growth, metabolism and vascular activation. PLT‑based models have been reported to have significant value on the recurrence of malignant hepatic tumors. The present study aimed to investigate the effect of PLT count and 18 PLT‑based models on the prognosis of patients with malignant hepatic tumors. The clinical data from 189 patients with malignant hepatic tumors were retrospectively analyzed and used to calculate the scores of the 18 PLT‑based models. Receiver operating characteristic curve was used to determine the suitable cut‑off values of mortality and recurrence in patients with malignant hepatic tumors. The overall survival and cumulative recurrence rates of patients were calculated using Kaplan‑Meier survival curves and the difference was analyzed using log‑rank test. Multivariate analysis was performed to determine the independent risk factors of recurrence‑free survival and overall survival. In the present study, 11 models were considered as predictors of mortality (P<0.05) and six models were considered as predictors of recurrence (P<0.05). The results from multivariate analysis demonstrated that vascular cancer embolus, uric acid >231 µmol/l, hemoglobin >144 g/l and the Lok index model >0.695 were considered as independent risk factors of mortality (P<0.05). Furthermore, vascular cancer embolus, PLT to lymphocyte ratio (PLR) >175 and fibrosis‑4 (FIB‑4) >4.82 were independent factors of recurrence (P<0.05). In addition, the results from this study indicated that the Lok‑index could be considered as a predictor of the overall survival rate. In conclusion, the FIB‑4 and PLR model may be valuable for predicting the recurrence‑free rate of patients with malignant hepatic tumors.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Hu, C., Du, Q., Wang, Z., Pang, M., Wang, Y., Li, Y. ... Fan, H. (2020). Relationship between platelet‑based models and the prognosis of patients with malignant hepatic tumors. Oncology Letters, 19, 2384-2396. https://doi.org/10.3892/ol.2020.11317
MLA
Hu, C., Du, Q., Wang, Z., Pang, M., Wang, Y., Li, Y., Zhou, Y., Wang, H., Fan, H."Relationship between platelet‑based models and the prognosis of patients with malignant hepatic tumors". Oncology Letters 19.3 (2020): 2384-2396.
Chicago
Hu, C., Du, Q., Wang, Z., Pang, M., Wang, Y., Li, Y., Zhou, Y., Wang, H., Fan, H."Relationship between platelet‑based models and the prognosis of patients with malignant hepatic tumors". Oncology Letters 19, no. 3 (2020): 2384-2396. https://doi.org/10.3892/ol.2020.11317