Open Access

Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis

  • Authors:
    • Ling Song
    • Yueqin Qi
    • Ming Lin
  • View Affiliations

  • Published online on: January 17, 2020     https://doi.org/10.3892/ol.2020.11314
  • Pages: 2489-2494
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long noncoding RNA placenta‑specific 2 (PLAC2) blocks the cancer cell cycle in glioma, suggesting its tumor‑suppressive role. The present study aimed to investigate the role of PLAC2 in retinoblastoma (Rb). It was found that PLAC2 was downregulated in Rb tissues and was not affected by the development of Rb. PTEN was also downregulated in Rb and positively correlated with PLAC2. In Rb cells, PLAC2 over‑expression resulted in the upregulated expression of PTEN, while PTEN over‑expression did not affect PLAC2 expression. PLAC2 and PTEN over‑expression caused an increased apoptotic rate of Rb cells. PTEN small interfering RNA silencing led to a decreased apoptotic rate and attenuated the effects of PLAC2 over‑expression. Therefore, PLAC2 regulates PTEN in Rb and participates in the regulation of cancer cell apoptosis.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Song, L., Qi, Y., & Lin, M. (2020). Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis. Oncology Letters, 19, 2489-2494. https://doi.org/10.3892/ol.2020.11314
MLA
Song, L., Qi, Y., Lin, M."Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis". Oncology Letters 19.3 (2020): 2489-2494.
Chicago
Song, L., Qi, Y., Lin, M."Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis". Oncology Letters 19, no. 3 (2020): 2489-2494. https://doi.org/10.3892/ol.2020.11314