Open Access

NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)

  • Authors:
    • Magdalena Ciążyńska
    • Igor A. Bednarski
    • Karolina Wódz
    • Joanna Narbutt
    • Aleksandra Lesiak
  • View Affiliations

  • Published online on: January 9, 2020     https://doi.org/10.3892/ol.2020.11284
  • Pages: 1649-1656
  • Copyright: © Ciążyńska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammasomes are key innate immune system receptors that detect pathogenic endo‑ and exogenous stressors like microorganisms or ultraviolet radiation (UVR) which activate the highly proinflammatory cytokines interleukin‑1β and interleukin‑18. Inflammasomes are not only involved in inflammation, but also in carcinogenesis and tumor progression. Due to the dynamic increase in non‑melanoma skin cancers (NMSC), it has become necessary to determine how UVR, which plays a key role in NMSC development, can regulate the structure and function of inflammasomes. In the present study, the regulatory mechanisms of NOD‑Like Receptor Family Pyrin Domain Containing 1 and 3 inflammasome activation as well as an effective inflammasome‑mediated immune response after UVR exposition are discussed. The differences and similarities between these molecular complexes that monitor cellular health, inflammation, and skin carcinogenesis are also highlighted. Despite numerous scientific data, more studies are still required to better understand the biology of inflammasomes in skin cancer development and to explore their therapeutic potential.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Ciążyńska, M., Bednarski, I.A., Wódz, K., Narbutt, J., & Lesiak, A. (2020). NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review). Oncology Letters, 19, 1649-1656. https://doi.org/10.3892/ol.2020.11284
MLA
Ciążyńska, M., Bednarski, I. A., Wódz, K., Narbutt, J., Lesiak, A."NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)". Oncology Letters 19.3 (2020): 1649-1656.
Chicago
Ciążyńska, M., Bednarski, I. A., Wódz, K., Narbutt, J., Lesiak, A."NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)". Oncology Letters 19, no. 3 (2020): 1649-1656. https://doi.org/10.3892/ol.2020.11284