Open Access

Increased ski expression levels are associated with a higher risk and poor prognosis in patients with gastrointestinal stromal tumors

  • Authors:
    • Qiu‑Shi Wang
    • Yu Zhai
    • Ping Li
    • Hua‑Liang Xiao
    • Yuan‑Guo Zhou
  • View Affiliations

  • Published online on: January 9, 2020     https://doi.org/10.3892/ol.2020.11280
  • Pages: 1735-1740
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastrointestinal stromal tumors (GISTs) are the most commonly diagnosed primary mesenchymal tumors of the gastrointestinal tract and 30% of GISTs are associated with a high recurrence risk or metastasis. The current risk classification criteria of the National Comprehensive Cancer Network are based on tumor size, mitotic activity and localization. Investigating additional biomarkers associated with clinical risk may aid in the diagnosis of GIST and improves prediction of patient prognosis. In the present study, the value of using the expression levels of the oncoprotein ski as a prognostic predictor for GISTs was investigated. The results demonstrated that high ski expression levels were correlated with high risk and recurrence rates and indicated poor prognosis regarding median disease‑free survival. Overall, the present study suggests that ski expression levels may serve as a predictor for clinical risk and prognosis of patients with GISTs.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, Q., Zhai, Y., Li, P., Xiao, H., & Zhou, Y. (2020). Increased ski expression levels are associated with a higher risk and poor prognosis in patients with gastrointestinal stromal tumors. Oncology Letters, 19, 1735-1740. https://doi.org/10.3892/ol.2020.11280
MLA
Wang, Q., Zhai, Y., Li, P., Xiao, H., Zhou, Y."Increased ski expression levels are associated with a higher risk and poor prognosis in patients with gastrointestinal stromal tumors". Oncology Letters 19.3 (2020): 1735-1740.
Chicago
Wang, Q., Zhai, Y., Li, P., Xiao, H., Zhou, Y."Increased ski expression levels are associated with a higher risk and poor prognosis in patients with gastrointestinal stromal tumors". Oncology Letters 19, no. 3 (2020): 1735-1740. https://doi.org/10.3892/ol.2020.11280