Increased ski expression levels are associated with a higher risk and poor prognosis in patients with gastrointestinal stromal tumors
- Qiu‑Shi Wang
- Yu Zhai
- Ping Li
- Hua‑Liang Xiao
- Yuan‑Guo Zhou
Affiliations: Molecular Biology Center, State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, The Army Medical University, Chongqing 400042, P.R. China, Department of Pathology, Daping Hospital and Research Institute of Surgery, The Army Medical University, Chongqing 400042, P.R. China
- Published online on: January 9, 2020 https://doi.org/10.3892/ol.2020.11280
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Gastrointestinal stromal tumors (GISTs) are the most commonly diagnosed primary mesenchymal tumors of the gastrointestinal tract and 30% of GISTs are associated with a high recurrence risk or metastasis. The current risk classification criteria of the National Comprehensive Cancer Network are based on tumor size, mitotic activity and localization. Investigating additional biomarkers associated with clinical risk may aid in the diagnosis of GIST and improves prediction of patient prognosis. In the present study, the value of using the expression levels of the oncoprotein ski as a prognostic predictor for GISTs was investigated. The results demonstrated that high ski expression levels were correlated with high risk and recurrence rates and indicated poor prognosis regarding median disease‑free survival. Overall, the present study suggests that ski expression levels may serve as a predictor for clinical risk and prognosis of patients with GISTs.