Open Access

THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors

  • Authors:
    • Heng Jiao
    • Lingxiao Zeng
    • Jianpeng Zhang
    • Shengsheng Yang
    • Wenhui Lou
  • View Affiliations

  • Published online on: January 9, 2020     https://doi.org/10.3892/ol.2020.11273
  • Pages: 1683-1692
  • Copyright: © Jiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vitro. MicroRNA(miR)‑744‑5p was indicated to be a direct regulator of THBS2. Upregulation of miR‑744‑5p potentially caused THBS2 repression. Furthermore, THBS2 inhibited the production of matrix metalloproteinase (MMP) MMP9 through suppressing the transcriptional activity of CUT‑like homeobox 1 (CUX1). CUX1 and MMP9 mediated the effect of THBS2 on pNET proliferation and migration, respectively. The results of the present study revealed a mechanistic role for THBS2 in pNET proliferation and migration, indicating that THBS2 was downregulated by miR‑744‑5p and further affected the CUX1/MMP9 cascade, which promoted the development of pNET.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Jiao, H., Zeng, L., Zhang, J., Yang, S., & Lou, W. (2020). THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors. Oncology Letters, 19, 1683-1692. https://doi.org/10.3892/ol.2020.11273
MLA
Jiao, H., Zeng, L., Zhang, J., Yang, S., Lou, W."THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors". Oncology Letters 19.3 (2020): 1683-1692.
Chicago
Jiao, H., Zeng, L., Zhang, J., Yang, S., Lou, W."THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors". Oncology Letters 19, no. 3 (2020): 1683-1692. https://doi.org/10.3892/ol.2020.11273