Open Access

Overexpression of miR‑206 in osteosarcoma and its associated molecular mechanisms as assessed through TCGA and GEO databases

  • Authors:
    • Xiongfeng Xu
    • Bo Qiu
    • Peng Yi
    • Huajie Li
  • View Affiliations

  • Published online on: January 8, 2020     https://doi.org/10.3892/ol.2020.11270
  • Pages: 1751-1758
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma (OS) is a primary malignant bone tumor that predominantly occurs in adolescents. Different types of OS tumor are highly malignant, associated with a poor prognosis and are invasive with blood‑vessel dissemination characteristics, thus affected patients are prone to early lung metastasis. MicroRNAs (miRNAs/miR) are small non‑coding RNA molecules that act as oncogenes or tumor suppressors during tumor development. The present study investigated the role of miR‑206 in OS development. Bioinformatics analysis demonstrated that miR‑206 was upregulated in OS and thus may serve as a risk factor for cancer prognosis. Subsequently, in response to miR‑206 overexpression, differentially expressed genes were screened and analyzed using the Database for Annotation, Visualization and Integrated Discovery, Gene Ontology enrichment analysis, the Kyoto Encyclopedia of Genes and Genomes pathways and protein‑protein interaction network construction, in order to identify key miR‑206 targets. The results demonstrated that high miR‑206 expression inhibited OS cell proliferation, which was associated with a good patient prognosis. Thus, miR‑206 may serve as a potential target for OS treatment, in order to improve early disease diagnosis.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Xu, X., Qiu, B., Yi, P., & Li, H. (2020). Overexpression of miR‑206 in osteosarcoma and its associated molecular mechanisms as assessed through TCGA and GEO databases. Oncology Letters, 19, 1751-1758. https://doi.org/10.3892/ol.2020.11270
MLA
Xu, X., Qiu, B., Yi, P., Li, H."Overexpression of miR‑206 in osteosarcoma and its associated molecular mechanisms as assessed through TCGA and GEO databases". Oncology Letters 19.3 (2020): 1751-1758.
Chicago
Xu, X., Qiu, B., Yi, P., Li, H."Overexpression of miR‑206 in osteosarcoma and its associated molecular mechanisms as assessed through TCGA and GEO databases". Oncology Letters 19, no. 3 (2020): 1751-1758. https://doi.org/10.3892/ol.2020.11270