Open Access

Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers

  • Authors:
    • Shou‑Feng Zhao
    • Xue‑Jing Yin
    • Wen‑Ju Zhao
    • Le‑Cui Liu
    • Zhi‑Peng Wang
  • View Affiliations

  • Published online on: January 8, 2020     https://doi.org/10.3892/ol.2020.11266
  • Pages: 1673-1682
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Biglycan (BGN), a key member of the small leucine‑rich proteoglycan family, is an important component of the extracellular matrix. Clinical studies have demonstrated that upregulation of BGN is associated with poor prognosis in patients with various types of solid cancer. The present study analyzed the mRNA expression levels of BGN in various types of solid cancer when compared with that in normal tissues via the Oncomine database. The UALCAN, OncoLnc and Kaplan‑Meier Plotter databases were additionally used to evaluate the prognostic values of BGN in patients with solid cancer and co‑expression gene analysis was conducted using the protein‑protein interaction networks of BGN. The present study observed that the mRNA expression levels of BGN were increased in bladder, brain and central nervous system, breast, colorectal, esophageal, gastric, head and neck, lung, ovarian and 28 subtypes of cancer compared with normal tissues. The increased expression of BGN was identified to be associated with a poor outcome in ovarian and gastric cancer. Based on the co‑expression network, BGN was identified as the key gene in a 43‑gene network. The present findings of increased expression of BGN in solid tumors and its positive association with poor outcome on patient survival indicate that BGN may serve as a prognostic marker and as a target for novel therapeutics for multiple types of cancer.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhao, S., Yin, X., Zhao, W., Liu, L., & Wang, Z. (2020). Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers. Oncology Letters, 19, 1673-1682. https://doi.org/10.3892/ol.2020.11266
MLA
Zhao, S., Yin, X., Zhao, W., Liu, L., Wang, Z."Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers". Oncology Letters 19.3 (2020): 1673-1682.
Chicago
Zhao, S., Yin, X., Zhao, W., Liu, L., Wang, Z."Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers". Oncology Letters 19, no. 3 (2020): 1673-1682. https://doi.org/10.3892/ol.2020.11266