Open Access

Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer

  • Authors:
    • Yakun Hu
    • Yuchen Yan
    • Yang Xu
    • He Yang
    • Lisha Fang
    • Yongli Liu
    • Xin Li
    • Qiang Li
    • Hongchao Yan
  • View Affiliations

  • Published online on: December 12, 2019     https://doi.org/10.3892/ol.2019.11213
  • Pages: 1281-1290
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Expression and clinical significance of WW domain‑containing oxidoreductase (WWOX), Elf5, Snail1 and epithelial‑mesenchymal transition (EMT) related factors in epithelial ovarian cancer were investigated. Ovarian cancer tissues of 300 epithelial ovarian cancer patients and the adjacent normal tissues were analyzed. Immunohistochemical method was used to detect the expressions of WWOX, Elf5, Snail1 and EMT marker molecules in the specimens. The relationship between the indicators and clinicopathological parameters, and prognosis of patients with ovarian cancer was analyzed. The relationship between WWOX, Elf5, Snail1 and EMT marker molecules E‑cadherin, N‑cadherin and vimentin in ovarian cancer tissues was analyzed. The expression levels of WWOX, Elf5, Snail1 and EMT marker molecules in epithelial ovarian cancer tissues were significantly different from those in adjacent normal tissues, and were related to surgical pathological stage, pathological grade and lymph node metastasis. High expressions of WWOX and Elf5 were related to the survival rate of patients. The survival rate of patients with positive expression was significantly higher than that of negative expression. FIGO stage, pathological grade, lymph node metastasis and expression of WWOX and Elf5 were all independent factors affecting postoperative prognosis in ovarian cancer patients. In conclusion, the expression levels of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer tissues are consistent and different. The expression levels of WWOX and Elf5 are related to the survival and prognosis of patients with epithelial ovarian cancer.
View Figures
View References

Related Articles

Journal Cover

February 2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Hu, Y., Yan, Y., Xu, Y., Yang, H., Fang, L., Liu, Y. ... Yan, H. (2020). Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer. Oncology Letters, 19, 1281-1290. https://doi.org/10.3892/ol.2019.11213
MLA
Hu, Y., Yan, Y., Xu, Y., Yang, H., Fang, L., Liu, Y., Li, X., Li, Q., Yan, H."Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer". Oncology Letters 19.2 (2020): 1281-1290.
Chicago
Hu, Y., Yan, Y., Xu, Y., Yang, H., Fang, L., Liu, Y., Li, X., Li, Q., Yan, H."Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer". Oncology Letters 19, no. 2 (2020): 1281-1290. https://doi.org/10.3892/ol.2019.11213