Open Access

Poly (ADP‑ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation‑associated chemotherapy‑induced autophagy in leukaemia cells

  • Authors:
    • Yunyao Li
    • Jianwei Xie
    • Xinyu Li
    • Jianpei Fang
  • View Affiliations

  • Published online on: November 19, 2019     https://doi.org/10.3892/ol.2019.11116
  • Pages: 368-378
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute lymphoblastic leukaemia (ALL) is one of the most common and curable types of cancer in paediatric patients. However, chemotherapeutic resistance is a difficult but common obstacle when treating leukaemia in the clinical setting. Studies have demonstrated that drug resistance is partly attributable to autophagy induced by multiple chemotherapeutic agents. As an evolutionarily conserved non‑histone chromatin‑binding protein, high mobility group box protein 1 (HMGB1) is considered to be an important factor in autophagy, and regulates autophagy at multiple levels via different subcellular localisations. In the present study, it was revealed that chemotherapeutic drugs induced autophagy in leukaemia cells and that translocation of HMGB1 from the nucleus to the cytoplasm is an important molecular event in this process. It was further demonstrated that poly (ADP‑ribosylation) of HMGB1 facilitates its acetylation, thereby inducing HMGB1 translocation and ultimately promoting chemotherapy‑induced autophagy in leukaemic cells. Targeted HMGB1 translocation may overcome chemotherapy‑induced autophagy in leukaemia.
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January 2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Li, Y., Xie, J., Li, X., & Fang, J. (2020). Poly (ADP‑ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation‑associated chemotherapy‑induced autophagy in leukaemia cells. Oncology Letters, 19, 368-378. https://doi.org/10.3892/ol.2019.11116
MLA
Li, Y., Xie, J., Li, X., Fang, J."Poly (ADP‑ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation‑associated chemotherapy‑induced autophagy in leukaemia cells". Oncology Letters 19.1 (2020): 368-378.
Chicago
Li, Y., Xie, J., Li, X., Fang, J."Poly (ADP‑ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation‑associated chemotherapy‑induced autophagy in leukaemia cells". Oncology Letters 19, no. 1 (2020): 368-378. https://doi.org/10.3892/ol.2019.11116